25 results
The primary aim is to investigate whether six weeks augmentation with clonidine of the antipsychotic treatment will reduce positive and negative symptomatology of treatment resistant schizophrenia patients. Important secondary goals of this project…
1.Social CognitiveA.Do schizophrenia patients, compared to unaffected controls, show impaired social cognition (perceiving, understanding, intentions and emotions of others), especially when it comes to self-other distinction processes (…
The primary aim of this study is to examine whether TAU plus MBT-P has a more positive effect on social functioning than TAU only.Secondly it will be examined whether this potential therapeutic effect is driven by an increase in social cognitive…
Primary objective is to compare all cause discontinuation rates in patients with schizophrenia randomized to either one of the two depot medications (aripiprazole depot or paliperidone palmitate) with patients randomized to either one of the two…
The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…
- To establish a model for TDM and calculate the AUC in patients treated with clozapine.- To clinically validate the DBS analysis method for clozapine. - To determine which sample points or combination of sample point(s) gives the best estimate of…
To examine whether symptoms of dissociation in schizophrenia are qualitatively similar or different to symptoms of dissociation in dissociative disorders.
The first goal of this research is to translate the IMI-SR into a valid and reliable Dutch version of this questionnaire (N-IMI-SR). The second objective is to assess whether there is an association between IM and cognition in schizophrenia.
Primary objective of the study is to investigate whether Behavioral Activation for Negative Symptoms (BANS) improves negative symptoms. Secondary objective is to investigate whether effects of BANS on negative symptoms is mediated or moderated by…
To evaluate the applicability and (cost-) effectiveness of a shortened, partly group based, Cognitive Behavioural Therapy (CBTsa) focussing on social activation in patients with recent onset schizophrenia.
The study will be performed in 2 parts, Parts 1 and 2. The volunteers can only participate in one of the two parts of this study. The purpose of Part 1 of the study is to investigate to what extent RO6806127 is tolerated. It will also be…
Main objective Part 1: To assess the safety and tolerability of RO6799477 after multiple ascending oral doses in healthy volunteers.Part 2: To assess the safety and tolerability of RO6799477 after multiple oral doses in patients with type 2 diabetes…
The objective of this project is to assess the applicability of [18F]PK209 for in vivo imaging of the NMDA receptor.
The objective of this study is to see wether the use of eye movement (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger study, in…
The effect of Eye Movement Desensitization and Reprocessing on Psychosis: A multiple baseline study.
This study will examine the effectiveness of EMDR in the treatment of psychosis, in patients without PTSD. Primary objective of this study is a first exploration of the efficacy of EMDR in the reduction of psychotic symptoms, perceived power of…
In the last ten years there has been a lot of research to understand persecutory delusions, but these findings had not yet been translated into treatment until Freeman and colleagues (2011). They targeted worry, but showed that rumination has to be…
In preparation for a multicentre randomized controlled trial (RCT) we want to test the psychomotor assertiveness training in a feasibility study. The aim of this study is threefold: 1) We want to evaluate and improve intervention protocol also using…
-to investigate the mass balance following a single oral dose of 14C-labeled research medication-to investigate the pharmacokinetics of total radioactivity in plasma and whole blood-to investigate and quantitate metabolites of the research…
The aim of this study is to demonstrate the influence of a serious diagnosis like schizophrenia has happiness in relation to daily activities.
P.11: This study seeks to contribute to our understanding of factors which contribute to violence in persons diagnosed with psychotic disorders, in order to improve clinical risk assessment and guide treatment choices.