16 results
The objective of the current study is to obtain normative data of healthy individuals on brain measures, cognition and blood markers. In addition, we acquire information on childhood trauma, metabolic and immunological parameters in a cohort of…
Primary Objective: The aim of this study is to determine the time to all-cause discontinuation of penfluridol (acemap; oral long acting neuroleptic) as compared to second-generation oral neuroleptics (olanzapine, risperidone) using an open label…
Primary objectives:* To explore the comparative bioavailability between 12.5 mg of Risperdal® Consta® prepared from a 25 mg dose strength of Risperdal® Consta® EU-sourced, and 12.5 mg of Risperdal® Consta® prepared from a 12.5 mg dose strength…
Empathy is related to quality of life, depression, insight and social functioning and may be an important factor in recovery of people with schizophrenia. Empathy is impaired in schizophrenia, however it is not clear which elements of empathy are…
In the current project we will investigate multiple risk factors and their interaction in a single study design, aiming to identify different profiles associated with social withdrawal behaviour in an Ultrahigh Risk and First Episode Psychosis…
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in first episode psychosis patients, i.e. at onset of illness. We seek to assess whether deficits in M1…
To assess the prospective relationship between social defeat on one hand and psychosis and crime on the other hand in Antillean immigrants to Rotterdam.
The proposed study aims to investigate the effects of a psychomotor assertiveness training by means of a multicentre randomized controlled trial (RCT). Effects will be examined at the behavioural level by means of questionnaires and interviews, and…
zie Nederlandse versie; na overleg met uw eigen METC werd vermeld dat een Engelstalige versie niet nodig was.
Primary:-To assess whether the genetic architecture of this severe SCZ phenotype differs from the broad DSM-based SCZ phenotypeSecondary:-To detect genetic associations with the current severe SCZ phenotype (case-control comparison)-To unravel…
Primary: To assess whether the genetic architecture of this severe SCZ phenotype differs from the broad DSM-based SCZ phenotype.To predict response and side effects after clozapine intakeSecondary:1. To detect genetic associations with the current…
To investigate whether methylation patterns/levels and gene expression profiles predict treatment outcome after initiating CLZ.
The primary objective of this study is to determine if the binding of [11C]PK11195, as a measure of neuroinflammation, in schizophrenic patients is decreased after simvastatin treatment.
The primary objective is to test the effects of temstem on distress, disturbance to life and social functioning. Second, we aim to investigate the effect of temstem on frequency and severity of AVH, to determine working mechanisms, to identify…
The aim of this project is to determine the value of a dynamic network approach to predict illness course and outcome of early psychotic symptoms.
Managing victimization risks attached to societal participation by people with severe mental illness
The main objective of the study is to gain insight in the effectiveness of the Victoria modules, in terms of acknowledgement for these experiences and risk awareness. These experiences and insights can be used to take acceptable risks in…