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(Cost-)effectiveness of a guided online CBT intervention in comparison to care-as-usual for patients with insomnia in general practice

Primary Objective: To determine the effectiveness of guided CBT compared to care-as-usual in treating insomnia in the general practice.Secondary Objective(s): Secondary objectives include investigation of cost-effectiveness. Several variables will…

A Randomized, Double-Blind, Placebo- and Active-Controlled, 4 Period Crossover Study to Evaluate the Effect of Lemborexant versus Placebo on Driving Performance in Healthy Adult and Elderly Subjects.

Primary ObjectiveThe primary objective of the study is to evaluate the effect of lemborexant 2.5, 5, and 10 mg compared to placebo on standard deviation of lateral position (SDLP) during an on-road driving test in the morning following a single dose…

A double-blind, randomized, controlled, 3-way crossover, pilot study to evaluate the duration of effects on simulated car driving and cognitive performance after a single dose of JNJ-42847922, zolpidem and placebo in healthy subjects

To evaluate the effects of JNJ-42847922, compared to zolpidem and placebo, on driving performance as assessed by the mean difference of standard deviation of lateral position (SDLP) after forced awakening using a validated driving simulator test at…

A randomized, placebo-controlled, 2-way crossover, double-blind study to evaluate the efficacy, safety and tolerability of JNJ-42847922 in subjects with insomnia disorder without psychiatric comorbidity.

The purpose of this study is to see if JNJ-42847922 is useful for treating patients with insomnia without any other psychiatric disease. The safety of JNJ-42847922 will also be studied.