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A double-blind, randomized, placebo-controlled, double-dummy, four-way crossover study to investigate the drug-drug interactions between ACT-541468 and ethanol in healthy subjects

To evaluate the pharmacodynamic (PD) effects of the study treatments (ACT-541468 50 mg, ethanol at a blood level of 0.6 g/L for 5 h) as co-administration in 4 different combinations (ACT-541468 plus ethanol, ACT-541468 alone, ethanol alone, and…

The SMILE study:Sleep Mood Intervention: Live Effectively
a group intervention in students with sleep problems

This is the first study to create and investigate the effectiveness of a multi-component intervention protocol in students with sleep problems. The aim is that such an intervention, combining cognitive-behavioural therapy for insomnia, mindfulness,…

Testing the effectiveness of online cognitive behavioral therapy for insomnia compared to waiting list on sleep-efficiency in adolescent and young adults after childhood cancer.

Objectives: 1) to evaluate the effectiveness of the e-CBT-i *i-Sleep* compared to a waiting list condition on sleep efficiency at 3, 6 and 12 months in ACC. 2) to assess the effects of eCBT-I on secondary outcomes: fatigue, quality of life, chronic…