109 results
Main: 1. To investigate whether a short term CBT-based group program is more effective in reducing symptoms of depression and anxiety than treatment as usual (TAU), among adolescents aged 10-16 within residential treatment settings in the youth…
The main objective of the study is to investigate whether a 9 week MFT for adolescents with ASD and clinically elevated internalizing symptoms, reduces adolescent's internalizing symptoms. Secondary objective is to investigate the process of…
The effectiveness of psychotherapy can be improved by increasing the frequency of sessions at the beginning of therapy. In addition, understanding processes that account for therapeutic change might enable us to optimize treatments.
Compare the clinical- and cost-effectiveness of blended cognitive behavioral treatment (bCBT) to treatment as usual (TAU) for adults with MDD in specialised ambulatory mental healthcare.
We will examine effectiveness of the internet-based self-help intervention compared to a waiting list control condition on (1) reduction of depressive and anxiety symptoms post intervention and 6 weeks post-partum and (2) improvement in perinatal…
This pilot cost-effectiveness study will compare blended cognitive behavioral treatment (bCBT) with standard face-to-face CBT (CBTAU) among patients with a diagnosis of major depressive disorder (MDD), who are treated in outpatient specialized…
The aim of this study is to investigate the effectiveness and the cost-effectiveness of the individual CBT program the *D(o)epressie cursus* by means of the following hypotheses;1. Is the individual CBT program the *D(o)epressie cursus* more…
The primary objective of this trial is to determine the clinical and cost effectiveness of computerized cognitive behavioural therapy with therapist support, compared to face-to face therapy based on cognitive-behavioural techniques for mild to…
The objective of the study is to gain preliminary insight in the efficacy of MBCT in the prevention of recurrence of depression in SAD patients.
To compare cerebral activity patterns during emotional and cognitive processing among patients with post-MI depression and patients with regular depression.
(1) This study will examine the effectiveness of CT and ACT in a randomized controlled trial conducted in a clinical setting. (2) Apart from being interested in differential effectiveness of the two approaches, we are also interested in whether…
a. To introduce apathy and related neuropsychiatric symptoms of depression and cognitive impairment as new outcome parameters in acute stroke trials, and study their impact on functional recovery. b. To study if two new treatments, evaluated in…
Following an oral dose of 1 mg [14C]-labeled RO4917523 of 2.22 MBq (60uCi) and an intravenous tracer dose of 0.1 mg [13C]-labeled RO4917523:Primary:To characterize the mass balance, metabolism routes and rates of elimination of [14C]-labeled…
part 1: to assess the absolute bioavailability of SCH900777part 2: to characterize the absorption, metabolism and excretion of SCH 900777to evaluate the safety and tolerability of SCH 900777 in healthy subjects
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PrimaryTo evaluate the pharmacokinetics of two different tablet formulations of BCI-952 compared to the over-encapsulated BCI-952 product components.SecondaryTo evaluate the safety and tolerability following the administration of two different…
Our primary aim is to test whether SFT is a suitable and effective treatment for chronic depression in terms of acute effects and the prevention of early relapse. Our secondary aim is to identify the underlying mechanisms of change in SFT that lead…
The primary aim of ICT4D is to design an intelligent monitoring and selfhelpsystem for use in Primary Care (Moodbuster). In this pilot study the feasibility and the usability if this intervention is tested among patients suffering from minor and…
This randomized controlled trial examines whether a guided-self-help intervention is effective in treating depressive symptoms by employees. Cost effectiveness is also examined.
Primary objective:To show that concomitant use of telaprevir (1125 mg BID) does not lead to a relevant decrease (> 20%) in the paroxetine parameter AUC0-24h compared to paroxetine alone.Secondary objectives:To determine the ratio of the…