55 results
The purpose of the study is to conduct a randomized controlled trial with the self-help intervention *Voluit leven* for adults with mild to moderate psychological distress. The research question is: What are the effects of the preventive self-help…
This study aims to test the efficiency and cost-effectiveness of a brief collaborative care intervention (primary objective). Assessment of patient wellbeing and (social) functioning are the secondary objectives.
1.Is the unilateral ultra-briefpulse stimulation used in this study as effective as briefpulse stimulation for the acute treatment of depression?2.Do the studied characteristics of the electrical stimulation -used to induce a seizure- differ in…
The aim of the study is to:1. assess the prevalence of depression in patients with somatic illnesses admitted to the general hospital and to examine which self-report questionnaire is most suitable to screen for depression in this setting;2. to…
The current pilot study aims to examine the feasibility of the module when added to an existing problem-solving intervention, *Alles onder Controle*, for reducing symptoms of anxiety and depression. Additionally, we aim to get first insight in…
This study attempts to explore the relation between the functioning of the schema-related mPFC, REM sleep and affective memory bias, by simulating a depressive-like state in healthy subjects through negative mood induction and applying rTMS to…
Primary ObjectiveTo evaluate the effect of a single 84-mg dose of intranasal esketamine compared to placebo, on next day driving performance and repeated administration of 84 mg intranasal esketamine on same-day driving performance as assessed by…
To examine whether adding yoga-based therapy (YBT) to treatment as usual (TAU) for young women with MDD leads to (1) greater reductions in symptoms and (2) greater cost-effectiveness in that the economic benefits of adding YBT to TAU outweigh the…
In this study, we want to combine rTMS and CCT to assess whether the combination of these two treatment would have synergistic effects and strengthen each other. We specifically want to assess the effect on mood and cognitive control, in a group of…
We aim to investigate the relationship between positive schema activation and subsequent tests of emotional schema memory, and whether tDSC during positive schema activation can facilitate retrieval of emotional memory for positive information in…
Hypothesis: 5 day multi daily neuronavigated Theta burst sessions (developed by Stanford University and coined, SNT, i.e. Stanford NeuromdulaTion protocol) are more (cost-) effective than standard 10 Hz rTMS in patients with treatment resistant…
To study the effectiveness of physiotherapy plus an eHealth psychological intervention targeted at psychosocial risk factors compared to usual physiotherapy care on disability, for patients at risk of developing persistent low back pain and neck…
The main objective is to investigate whether trauma-focused therapy (TFT), as an addition to *treatment as usual* (TAU), is more effective compared to TAU only in reducing depression symptom severity in patients with CT-related depression.
Primary objective:To deliver an easy accessible, patient friendly and low-cost self-help intervention for the treatment of depressive symptoms in dialysis patients.Main hypothesis: An eHealth CBT intervention reduces depressive symptoms in dialysis…
The primary aim of this study is to investigate the feasibility, acceptability and user-friendliness of implementing PM+ in Dutch prisons. This is a version of PM+ that is specifically adapted to the prisoner population and prison context. The…
To investigate the added effectiveness of Preventive Cognitive Therapy (PCT) with oNCRT as compared to PCT on depressive symptomatology over a one-year period in 115 partially remitted depressed patients. We hypothesize that oNCRT is able to augment…
Primary objective:To assess whether the state of premature immune aging (senescent CD8+ T cells) predicts treatment response to physical endurance intervention therapy in depressed patients. We will compare the mood-beneficial effects of physical…
Objective/research question: What are costs and effects of group-oriented Psychiatric Rehabilitation ("Patient and Partner Education Program for All chronic diseases": PPEP4AII) in patients with Persistent Depressive Disorder and their…
Primary Objective: To determine whether NFE + standard care is superior to standard care alone in the treatment of depression. Secondary Objective(s): To assess correlations between NFE success and brain activation / clinical changes; to assess…
This study aims to investigate the effectiveness of EMDR (n=32) in comparison to a waiting list in (n=32) adolescents (12-18 years) with a primary diagnosis of MDD (DSM-5; American Psychiatric Association, 2013). It is hypothesized that the…