193 results
To examine whether indeed behavioral activation using the NiceDay smartphone app is more efficient and more effective in treating patients with unipolar depression than treatment as usual (TAU).
The goal of this research project is to evaluate effectiveness of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a co-morbid depressive symptoms. With the online guided…
To evaluate the relative oral bioavailability and dose proportionality of concept formulations compared with the reference formulation of aticaprant when administered in healthy adult participants. This part will be conducted by PRA.To evaluate the…
Since previous findings underline the hypothesis that ER may play a key role as an underlying mechanism leading to (re)victimisation, we suggest that a clinical intervention aimed at enhancing ER skills may decrease (re)victimisation risk. Therefore…
Objective 1: To determine the effects of S-ketamine on brain activation in healthy women, healthy women prone to depression and fibromyalgia patients.Objective 2: To determine the effects of S-ketamine on mood and other depression-related behavioral…
- To assess the effect of food (high-fat) on the bioavailability and pharmacokinetic (PK)- profile of a solid dosage formulation of JNJ-67953964.- To assess the effects of repeated QD administration of 200 mg of itraconazole (steady state) on the…
The study is a first step towards investigating whether VR, and more specifically changing automatic negative thoughts (ANT) and doing role play in a virtual world, is effective in treatment of a depressive disorder.
Is care as usual (CAU) with adjunct evidence-based prescription of exercise more effective than CAU alone in reducingdepressive symptoms in patients with major depressive disorder in the specialised mental health service setting?
Regarding the goal of the Society for Mental Space Psychology: to help shift the paradigm in psychology towards a more mental space oriented science, the publication of research that supports this idea is fundamental. Besides that, is the…
Primary Objective: - To examine the acceptability and feasibility of an add-on internet-based ERT training and the trial design in adolescent patients (aged 13-18) with depressive or anxiety disorders, their parents, and their therapists as…
The primary goal of this study is to understand how the Christian faith is associated with psychological flexibility and the effectiveness of specific ACT interventions. This makes a better assessment of choices in the ACT treatment of Christian…
Is the cognitive behavioural couterconditioning method an effective intervention for depressed older people? What factors predict or influence this?
This study has been transitioned to CTIS with ID 2024-517485-42-00 check the CTIS register for the current data. To investigate whether oral esketamine is non-inferior to ECT in achieving treatment response on depression severity in NTRD.
Primary Objective: To evaluate the feasibility and acceptability of the culturally and contextually adapted WHO*s PM+ intervention for Arabic, Tigrinya and Ukrainian speaking refugee youth living in the Netherlands.Secondary Objective:1. To evaluate…
Our primary goal is to develop an easy access cognitive training for older patients with mood disorders suffering from (subjective) cognitive complaints. We want to study the effect on both objective and subjective functioning. Secondary, we aim to…
The primary aim of this pilot study is to determine the acceptability of the intervention. The secondary aim is to elucidate factors that may facilitate or hinder the feasibility of the follow-up RCT (e.g., recruitment process) and to estimate the…
The objective of the present study is to investigate the influence of CBT-I on the serum levels of MDD biomarkers pertaining to the neuroendocrine, immunologic, neurotrophic, and metabolic hypotheses of MDD (primary objective) and explore whether…
The present study aims to examine if BA has a positive effect on the severity of depressive symptoms as measured by the PHQ-9 in adolescent depressive participants. In addition, several additional objectives are included (classification of the…
The purpose of this study is to investigate how safe the new compound JNJ55375515 is when it is administered to healthy subjects. JNJ-55375515 has been administered to humans before and will be investigated at various dose levels.It will also be…
Primary Objective: Primary aim of this study is to evaluate the effectiveness and cost-effectiveness of D(o)epression Blended in clinical practice in reducing depressive symptoms and disorders in clinically depressed adolescents. The modern and…