48 results
Objective: We would like to differentiate *normative mood swings*. in adolescence from early signs of depression. A comparison between low-risk adolescents and an at risk and a clinically referred sample is needed to detect an unrecognized subsample…
The objective of this study is to establish the (cost) effectiveness of transmural collaborative care including a Consultation Letter for the GP and duloxetine (TCCCL) versus Duloxetine in patients with depression that present themselves with (sub)…
The objective of this study is to gain better inside in decision-making in the treatment of mood and anxiety disorders and treatment preferences of both patients and clinicians. We will explore factors that determine decisions and look for possible…
To evaluate the cost-effectiveness of a nurse-led stepped-care program for depression among primary care patients with type 2 diabetes mellitus and/or coronary heart disease and subtresshold depression in comparison with usual care.
The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…
The goal of the current project is to examine the cost-effectiveness of an internet-based guided self-help intervention(Allesondercontrole.nu) for depression, in mental health care in comparison with usual care. This intervention has beendeveloped…
The primary objective of this study is to evaluate the long-term safety and tolerability of LY2216684 administered once daily (QD) in the adjunctive treatment with a selective serotonin reuptake inhibitor (SSRI) for up to approximately 1 year in…
We aim to (1) improve differential diagnosis of recurrent MDD and BD by investigating biomarkers at a neuropsychological and neurobiological level ; (2) investigate whether affective neuropsychological testing can be used as a diagnosios tool for…
Main objective: to get insight in the effectivity of the SAM on depressive symptoms, quality of life, activity level, mastery and costs compared to treatment as usual in clinical admitted depressive elderly.Sedundary objective: to get an insight in…
In this study the effect of adding graded task assignment to standard treatment with behavioral activation are examined on avoidance patterns in patients with depression. Treatment objectives will be granted by gradual task assignment into sub-…
To determine the influence of the serotonin transporter activity on the plasma free serotonin and dopamine amount and the stored amount (in trombocytes) in three different populations (healthy controls, carcinoid patients and patients on medication…
Our pragmatic trial aims to integrate a cost-effective innovative care intervention in regular primary care. The intervention needs to be adapted for practice nurses to detect mental health problems in physical chronic patients and to provide,…
The goal of this study is to develop and investigate the effectiveness and cost-effectiveness of a stepped-care programme for visually impaired older adults to diminish subthreshold depression and/or anxiety symptoms and to prevent a full depressive…
Improving primary care for patients with psychosocial symptoms by introducing the SGE-PsyScan.
Taking into account the challenges related to treatment of MDD in a PCP setting, a MDD assessment tool for PCPs will be developed with a twofold intent: a) to help PCPs to follow the progress of their MDD patients from the start of the AD treatment…
The primary aim of the study is to test the effectiveness of a collaborative care model for major depressive disorder for patients with DM, CVD, COPD, and HIV in the general hospital outpatient setting. Secondary aim is to estimate the cost-…
Observe the adherence rate of antidepressants during pregnancy and secondary exploration of possible factors which contribute to non-adherence
1) To examine whether adolescents with depression, show abnormalities during specific attentional processes, compared to normal controls, 2) To determine whether abnormalities in attentional processes can be considered as prognostic markers of a…
The purpose of this study is to develop a webbased intervention for breast cancer patients to reduce the impact of psychological problems that arise after the completion of medical treatment at an early stage. The question is whether this…
Primary:1. to investigate the serotonergic HPA-axis activation (cortisol, ACTH, prolactin) in patients with a major depressive episode, using a newly developed oral 5-HTP-challenge administered before the first ECT treatment.2. to investigate the…