99 results
To investigate the impact of the multispecies probiotic product Ecologic*Barrier on neurocognitive measures of emotion and executive functioning.
The primary objective of this study is to predict the antidepressant treatment outcome of ECT in patients with severe depressive symptomatology using neuroimaging. ECT itself is conducted as usual according to national guidelines (Nederlandse…
Aim of this study is to examine the mechanisms by which attachment style and emotion regulation relate to depressive symptoms and anxiety symptoms in a clinical and non-clinical Dutch population.
The present study will evaluate potential etiological models for sleep disturbances, depressive symptoms and cognitive impairment using an innovative idiographic design using time-series analysis that accounts for both intra-individual variability (…
The primary objective is to assess feasibility of a food supplement (multispecies probiotic) placebo-controlled, randomised controlled, double blind intervention in pregnant women in their late second/third trimester of pregnancy, to reduce symptoms…
The purpose of the present study is to investigate the effects of light therapy (with two different light boxes) on depression in people with intellectual disability (IQ *70 ) compared to standard care (care as usual).
The primary objectives are (1) to investigate the feasibility of online courses targeting nutrition and food-related behaviour and (2) to investigate whether the feasibility of the online courses is related to depressive symptoms. The secondary…
This study aims at the questions about anterograde amnesia. How often does it occur in patients being treated with bilateral ECT for a depressive disorder, how does anterograde amnesia develop during the treatment course and how does it subside…
Identification of genetic variations that control monoamine and amino acid metabolism in humans, by translating recent genetic findings in non-human primates to a human cohort.
Primary Objective: * To determine the effects of pharmacogenetic screening for CYP2D6 on the time to reach adequate serum drug levels according to the guidelines.Secondary Objective(s): * To determine the effects of pharmacogenetic screening for…
Overall, our primary research goal is to elucidate the underlying molecular and cellular neurobiology of depression. Specifically, this study will focus on the following key objectives:1. My first objective is centered on the major prevailing…
This study aims to investigate the neurobiological basis underlying the strong antidepressant effect of ECT in patients with unipolar and bipolar depression using MRI. We will also assess a potential neurobiological basis for the cognitive side-…
Aim of the study is to evaluate the effectiveness and cost-effectiveness of a positivity training based on attention bias modification as waitlist-intervention for adult outpatients with a major depressive disorder.
This study aims to investigate how serotonin influences social functioning in healthy adults with a first-degree family member diagnosed with MDD. The primary goal is to investigate the effect of an experimental increase in brain serotonin on…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
The objective of this pilot study is to investigate the association between hemodialysis-associated changes in tryptophan levels and changes in symptoms of depression and fatigue, and the temporal dynamics between depression and fatigue.
Primary Objective: 1. An explorative study to investigate whether a change in pain complaints or depressive symptoms can be predicted using baseline EEG/ERP measures derived from vulnerability experiments.Secondary Objective(s):1. To explore changes…
The study has 3 substudies with each their separate goals:Neuroimaging part:1. To determine the effects of DBS on D2 receptor binding. 2. To determine alterations in cerebral perfusion associated with deep brain stimulation (DBS).Neuropsychological…
We aim to answer the following research questions:Primary:1) Is a history of major depressive disorder associated with smaller volumes of the hippocampus and is this volume reduction disproportionate to the total brain volume?2) Are depression and…
The aim of this study is to investigate the temporal dynamics between depressive symptoms and physical activity in post-MI patients, in order to prevent the deleterious effects of depression on heart disease prognosis and improve patient counselling…