342 results
The aim of this study is to evaluate the long-term imaging and functional outcomes of overuse injuries of the wrist in (former) athletes.
The aim of the current project is to evaluate the long-term effects of a) a pragmatic lifestyle intervention aimed at weight loss and b) a 30-month placebo-controlled intervention with glucosamine sulphate on the development of knee osteoarthritis…
The objective of the study is to study the effect of Teripratide (rhPTH 1-34) on undercarboxylated osteocalcin levels, testosterone concentrations, glucose tolerance and insulin sensitivity in male subjects with primary osteoporosis.
The primary objective is to assess bone structure parameters and bone strength by high resolution peripheral quantitative CT evaluation (HRpQCT) and physical activity in relation with subsequent falls, fractures and mortality in patients with a…
To investigate the impact of 7 days of bed-rest on skeletal muscle mass, strength and whole-body insulin sensitivity in healthy, young men.
Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…
The primary objective is to study the effect of sensor monitoring embedded in an OT rehabilitation program for older persons after hip fracture on recovery of daily functioning, 6 months after the start of rehabilitation, as compared to coaching by…
This investigation aims to investigate connective tissue fibroblast activation in detail in the inflamed fibrotic connective tissue. By analyzing these cells in detail we hope to understand better how they are activated, so we can develop better and…
The objective of the study is to investigate vertebral bone marrow fat fraction and bone mineral density during surgery induced weight loss.
The objective is to study the effectiveness of the online self management training Reuma Uitgedaagd! voor adults with a rheumatic disease.
The primary objective is to test the hypothesis that a protein-rich nutritional supplement (containing 45 g of dietary protein) prior to surgery acutely increases skeletal muscle and bone protein synthesis rates in older patients undergoing a hip…
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
1. How does muscle overloading expressed by pain effect SB characteristics?2. What SB characteristics are associated with jaw-muscle pain?3. Are SB and psychological stress contributing factors for TMD pain?
The purpose of this study is to find out which common problems occur in the HME patient population. Furthermore the study will investigate which factors are associated with the observed problems. This is barely investigated in the current literature…
PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…
We want to find out whether the new protocol (with a fast MRI) is more cost-effective than the current protocol (concisting of 10 days cast). Primary Objective: To find out whether the new MRI protocol is more cost-effective than the old protocol.…
To investigate the pathophysiological link between RA and PD, and test the efficacy of RvE1 treatment in gingival tissue biopsies of RA-PD and RA risk-PD patients ex vivo.
The main objectives of the current study are to (i) examine whether fulfilment of expectations predicts patient satisfaction in a Dutch sample of TKA and THA patients; (ii) study which patient-related factors predict unrealistically high patient…
The aim of our study is to further elucidate the role of genetic factors in the pathogenesis of CTS by genetic and functional research.-Objective 1: Unravel the mutational spectrum of genes in patients with idiopathic CTS-Objective 2: Evaluation of…
PRIMARY OBJECTIVETo identify the cellular mechanism behind early antidrug antibody (ADAb) production related to humoral responses within first 3 months of BP treatment.SECONDARY OBJECTIVES- To identify the affinity maturation process in ADAb…