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Structural and Functional Microcirculatory Aspects of Patients with (suspected) Connective Tissue Disease and Pulmonary Arterial Hypertension

The proposed project focuses on: a) implementation of an improved, standardized method for performing quantitative nailfold capillaroscopy to visualize morphological patterns and evaluate its diagnostic use in patients with (possible) CTD and…

Biomarkers in Systemic Sclerosis

Construction of a biobank with peripheral blood and skin biopsies from patients with SSc, to evaluate (new) antigens and/or (new) antibodies and/or RNA expression profiles and to correlate these findings with clinical parameters (i.e. disease…

sexual function in female systemic sclerosis

HypothesisSexual function in female systemic sclerosis patients is impaired as a result of fibrosis of the genital tract, fatigue, chronic pain, Raynaud*s phenomenon and contractures. AimThe aim of the study is to investigate sexual function and its…

Genetic origin of Dupuytren*s disease and associated fibromatosis

The purpose of this study is to further unravel the genetic origin of these individual diseases and their relation at genes level.

Solis (PEEK) versus Solis (PLLA) resorbable cage for anterior cervical discectomy with fusion - Controlled randomized clinical outcomes study

The objective of this study is to compare short- and long-term surgical and clinical outcomes of patients with chronic neck pain and neck disability due to a single-level spinal disorder that undergo Anterior Cervical Discectomy followed by…

The HELI pilot: clinical research to investigate the possibility of fixation of the polypropylene mesh with autologous growth factor fibrin glue in hernia inguinalis surgery.

Using AGW gives a good fixation of the polypropylene mesh in hernia inguinalis surgery and will not lead to a higher recurrence rate. The maximum acceptable recurrence rate is 10% after 3 months.

Double blind, placebo controlled study Tacrolimus versus Emmolient in localized scleroderma

The primary objective of this study is to assess whether tacrolimus is effective for the treatment of morphea.

COLPOP
'"Collagen metabolism in patients with and without Pelvic Organ Prolapse; a pilot study*

To investigate the collagen metabolism in pelvic floor tissue, pelvic floor-derived fibroblasts, and adipose tissue stem cells in patients with and without pelvic organ prolapse (POP)