118 results
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
The objective of the study is to study the effect of Teripratide (rhPTH 1-34) on undercarboxylated osteocalcin levels, testosterone concentrations, glucose tolerance and insulin sensitivity in male subjects with primary osteoporosis.
The objective of this study is to evaluate whether an in- or outpatient initiation of the brace treatment has an influences short and long term brace compliance.
The objective of the study is to investigate vertebral bone marrow fat fraction and bone mineral density during surgery induced weight loss.
1. The primary objective is to evaluate the characteristics of the distal radial growth plate on MRI (including functional imaging techniques) and on conventional radiographs in young gymnasts with wrist pain, compared to young gymnasts without…
What is the most optimal treatment strategy for children / adolescents with knee complaints? Our hypothesis is (based on the invasive surgical procedure) patients that will be surgical treated (index group) have a clinical relevant gain of pain…
Our aim is to study whether the pain response after three months in patients with bone metastatic disease increases after SBRT in comparison to low dose EBRT.
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…
The aim of this prospective cohort study is threefold: (1) for a better understanding of MTSS' underlying pathophysiology, (2) to assess the QU's reliability in healthy subjects and subjects with MTSS and (3) to assess the validity of QU…
To investigate the long term stability (> 5 yrs) in patients treated with mandibular distraction osteogenesis (MDO) for correction of a Class II-occlusion. Hypotheses:1) MDO is a technique for mandibular lengthening with comparable stability…
Part 1: Quantification of individual patient-prosthesis interactions- Determination of the instantaneous effect of prosthetic knees with variable biomechanical properties on the gait pattern of PULAs (Part Ia). - Determination of the influence of…
This study aims to improve the first phase of rehabilitation after THA. The primary objective is to analyse the effect of feedback to the patients. The secondary objective is to quantify the weight bearing in the early phase after THA surgery.
In this exploratory pilot study, we aim to investigate the role of immune activation in osteoporosis in HIV-infected patients on HAART with proven osteoporosis/ osteopenia in comparison to HIV-infected patients on HAART without osteoporosis/…
• Compare bone density between patients with mild haemophilic and those with severe haemophilia*.• Compare the relationship between treatment regimen: prophylactic (high-dose vs. intermediate dose) and on-demand and bone density.• Examine the…
Primary Objective: - Are there mesurable changes in biochemical markers after BSSO in serum(CTX, P1NP, BALP, Osteocalcine, Calcium, vit D. CRP, BSE, leucocyten, IL6, creatine) and in urine(hydroxylysylpyridinoline en lysyspyridinoline)? - Can serum…
To increase to knowledge of how adults with OBPL function, this research will be done with de next researchquestion: what iare the lengterm consequences of OBPL among adults? These questions are being adressed to with fhe ICF structure:- body…
To investigate in vivo whether a measurable increase in systemic ATP levels occurs in response to mechanical stimulation of bone in humans.
Is the lateral chest X-ray useful to look for vertebral fractures using the semiquantative method of genant in the geriatric population? Our hypothesis is that the lateral chest X-ray is a good alternative, with high sensitivity and specificity…
It is our goal to predict the efficacy of glucocorticoid-treatment of RA patients by means of a list of markers predicting the reponse to GC treatment in order to avoid ineffective but potentially harmful treatment in the glucocorticoid non-…