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Effect of in- and outpatient brace adaptation protocols on brace compliance in adolescent patients with idiopathic scoliosis

The objective of this study is to evaluate whether an in- or outpatient initiation of the brace treatment has an influences short and long term brace compliance.

What is the most optimal treatment strategy for an adolescent with knee complaints?

What is the most optimal treatment strategy for children / adolescents with knee complaints? Our hypothesis is (based on the invasive surgical procedure) patients that will be surgical treated (index group) have a clinical relevant gain of pain…

Randomized controlled trial comparing conVEntional RadioTherapy with stereotactIC body radiotherapy in patients with spinAL metastases

Our aim is to study whether the pain response after three months in patients with bone metastatic disease increases after SBRT in comparison to low dose EBRT.

Pharmacokinetic study to assess the bioavailability of phenolics from an olive leaf extract

The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…

Longterm Skeletal Stability of Mandibular Distraction Osteogenesis

To investigate the long term stability (> 5 yrs) in patients treated with mandibular distraction osteogenesis (MDO) for correction of a Class II-occlusion. Hypotheses:1) MDO is a technique for mandibular lengthening with comparable stability…

SensiStep Study
Resumption of weight bearing among total hip prosthesis patients; a pilot study

This study aims to improve the first phase of rehabilitation after THA. The primary objective is to analyse the effect of feedback to the patients. The secondary objective is to quantify the weight bearing in the early phase after THA surgery.

Bone density as outcome parameter in haemophilia treatment

• Compare bone density between patients with mild haemophilic and those with severe haemophilia*.• Compare the relationship between treatment regimen: prophylactic (high-dose vs. intermediate dose) and on-demand and bone density.• Examine the…

Pilot study on the effect of mechanical stimulation of bone on ATP release in humans in vivo

To investigate in vivo whether a measurable increase in systemic ATP levels occurs in response to mechanical stimulation of bone in humans.

Differences in gene expression profile between Glucocorticoid-responsive and Glucocorticoid-nonresponsive patients with rheumatoid arthritis

It is our goal to predict the efficacy of glucocorticoid-treatment of RA patients by means of a list of markers predicting the reponse to GC treatment in order to avoid ineffective but potentially harmful treatment in the glucocorticoid non-…

Bone augmentation with autologous adipose tissue-derived mesenchymal stem cells and calcium phosphate carriers in the human maxillary sinus floor elevation model

> Primary Objective:This is a pilot study, aiming at the clinical evaluation with respect to safety and feasibility of a one-step surgical procedure for maxillary sinus floor augmentation for the placement of dental implants, using a ceramic…

Bioequivalence study for vitamin D3 pharmacokinetic parameters following single oral administrations of vitamin D3 1000 IU with cyclodextrin and vitamin D3 1000 IU without cyclodextrin in Caucasian healthy volunteers

The purpose of the study is to investigate whether the cyclodextrin added to the cholecalciferol formulation has an effect on the vitamin D3 availability in the body. Thus, it will be investigated if concentrations of vitamin D3 that are found in…

A Randomized Open-Label Study to Evaluate the Safety and Efficacy of Denosumab and Monthly Actonel® Therapies in Postmenopausal Women Transitioned from Weekly or Daily Alendronate Therapy

The primary objective of the study is to evaluate the effect of denosumab 60mg every 6 months (Q6M) compared with Actonel 150mg monthly (QM) on total hip Bone Mineral Density (BMD) at 12 months in postmenopausal women transitioning from previous…

A multicenter randomised study in which operative stabilization of rib fractures with a flail chest is compared with mechanical ventilation.

The Purpose of this study is to compare the surgical treatment of flail chest with the non-operative treatment regarding complications.Hypothesis: Surgical stabilization of rib fractures in flail chest results in fewer respiratory complications,…

Cervical spine movement, before and after anterior cervical discectomy (ACD).
ACD, pure intervertebral discectomy (1) compared to intervertebral discectomy followed by implantation of an intervertebral disc prosthesis (2) in patients with a radicular syndrome. A randomised study

Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.

Prospective comparison in new challenging gait and balance tasks in female adolescents with idiopathic scoliosis before and following corrective spinal fusion

The aim of the present study is to use a more complete analysis of spinal motion (using a 3D multi-segment spine model) and to introduce challenging gait tasks which can optimally reveal the compensation strategies of the spine. Furthermore, static…

Cost-effectiveness of nerve root decompression according to Gill versus instrumented fusion in the treatment of spondylolytic spondylolisthesis; a multicenter prospective randomised trial.

The Sciatica-Gill trial is a randomised cost-effective study about nerve root decompression according to Gill versus instrumented fusion in the treatment of patients with radicular legpain or neurogenic claudication due to spondylolytic…

The use of Progentix TCP (beta-tricalciumphosphate) as a bone substitute in defects originated from curettage of benign bone tumors

In patients with benign bone tumors, the defect originated from curretage of the tumor, will be filled with Progentix TCP. The bone regenerative capacity of Progentix TCP will be compared to the capacity of autologous bone (the golden standard).…

A Feasibility Study on the use of Percutaneous Instrumentation for less invasive surgery of Scoliosis Deformity in Children with Neuromuscular Disease.

To test the surgical feasibility of the less invasive percutaneous pedicle screw instrumentation system for the treatment of children with a so called "hypotonic" scoliosis. Additionally, postoperative pain reduction and a reduced hospital…

Vertebroplasty versus radiotherapy as palliative treatment of vertebral metastases of multiple myeloma (M. Kahler)

Compare vertebroplasty with radiotherapy regarding costs and effectivity in treating pain, restoring mobility, and improving quality of life.

Displaced midshaft fractures of the clavicle: non-operative treatment versus Synthes ® plate fixation. A multi-centre randomised controlled trial in the Netherlands.

Results of recent trials suggest that operative treatment with locking plate fixation results in better functional outcomes than non-operative treatment. Because more patients were lost to follow-up than anticipated in the main randomised trial,…