55 results
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
The objective of the study is to study the effect of Teripratide (rhPTH 1-34) on undercarboxylated osteocalcin levels, testosterone concentrations, glucose tolerance and insulin sensitivity in male subjects with primary osteoporosis.
The objective of the study is to investigate vertebral bone marrow fat fraction and bone mineral density during surgery induced weight loss.
1. The primary objective is to evaluate the characteristics of the distal radial growth plate on MRI (including functional imaging techniques) and on conventional radiographs in young gymnasts with wrist pain, compared to young gymnasts without…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
The aim of this prospective cohort study is threefold: (1) for a better understanding of MTSS' underlying pathophysiology, (2) to assess the QU's reliability in healthy subjects and subjects with MTSS and (3) to assess the validity of QU…
In this exploratory pilot study, we aim to investigate the role of immune activation in osteoporosis in HIV-infected patients on HAART with proven osteoporosis/ osteopenia in comparison to HIV-infected patients on HAART without osteoporosis/…
Primary Objective: - Are there mesurable changes in biochemical markers after BSSO in serum(CTX, P1NP, BALP, Osteocalcine, Calcium, vit D. CRP, BSE, leucocyten, IL6, creatine) and in urine(hydroxylysylpyridinoline en lysyspyridinoline)? - Can serum…
Is the lateral chest X-ray useful to look for vertebral fractures using the semiquantative method of genant in the geriatric population? Our hypothesis is that the lateral chest X-ray is a good alternative, with high sensitivity and specificity…
This pilot study will evaluate whether tumour hypoxia can be demonstrated in the bone marrow compartment of relapsing MM patients by using the tracer 18F-FAZA. The results will be compared with the results of the FDG-PET scan. In addition in vitro…
To investigate the differences in facial analysis, between patients with acromegaly, being in remission, and healthy subjects, and to investigate the changes in relational proportions between these facial structures.
To determine the incidence of vertebral fractures and exploring riscfactors in the geriatric outpatients.The effect of new vertebral fractures on daily activities, quality of life, reported falls.To explore the relation between frailty syndrome…
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
The objective is to study the effect of beta-agonist and beta-antagonist treatment on human bone remodeling.
Is DEXA accurate to predict bone loss of the femur before undergoing hip revision arthroplasty and provide a tool for quantification of bone loss of the femur before hip revision arthroplasty? Can DEXA be used to monitor bone remodelling after hip…
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
1.To investigate if [18F]Fluoride PET-CT is a potential imaging technique for assessment of (changes in) disease activity of ankylosing spondylitis on baseline and after anti-TNF therapy (with MRI and clinical outcome as reference).Sub-study in 2…
The objective of this study is to assess the diagmostic accuracy of microMRI to detect ROD in children with ESRD and metabolic bone disease by oxalosis in patients suffering from oxalosis.
The objective of the study is to study the effect of Teripratide (rhPTH 1-34) on undercarboxylated osteocalcin levels, testosterone concentrations, glucose tolerance and insulin sensitivity and changes in body composition in male subjects with…
The overall objective of this project is to gain more inside into the role of PPARγ in osteoclastogenesis, osteoclast differentiation and function.