76 results
Identification of the molecular and cellular muscular mechanisms associated with aging in rotator cuff muscles with radiological quantification and clinical data.
The primary aim of this study is to determine the effect of nandrolone decanoate (ND) injection and leucine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying…
Determine the reliability, validity and the sensitivity to change of the MYOTON Handheld Digital Palpation Device for measuring the severity of paratonia in patients with dementia and paratonia .Research questions are:(1) What is the validity of the…
We aim at investigating the role played by the innate and adaptive immune system and orienting a proper treatment. We will evaluate the percentage and features of circulating activated immune cells and cytokine production. As a second step, we will…
Primary Objective: To investigate whether differences exist in muscle function, muscle energy metabolism and cardiorespiratory fitness in CML patients with muscle complaints, compared to CML patients without muscle complaints, and controls (non-CML…
We aim at investigating the interplay between DUX4 and inflammation in FSHD combining MRI imaging, histology, gene and cytokine expression.
The primary objective of this study is to further discribe the natural course and clinical characteristic of infantile FSHD.The secondary objectives are: - To identify (epi)genetic and environmental disease modifying factors that contribute to…
In order to develop treatment strategies guided by the key mechanisms that play a role in dysphagia in OPMD and IBM, the exact pattern of weakness should be identified. The current protocol allows us to test the feasibility of two non-invasive…
The main goal of our study is to determine the function of DUX4 in the human thymus by obtaining residual tissue from inevitable (incomplete) thymectomies during open heart surgery in infants. Our primary objective is to detect germline and skeletal…
This study aims to isolate and culture myogenic stem cells called mesoangioblasts from the muscle biopsies to explore if genetic correction of LAMA2 mutations using CRISPR-Cas9 can be achieved and subsequently assess the effect in vitro, as a first…
The primary objective is to investigate the differences in mentalizing abilities between outpatients with chronic pain and a control group, consisting of outpatients with painful acute injuries or painful somatically explained conditions. The…
Primary objective: To investigate the prevalence of bruxism and TMD in PD patients through objective measurements and to identify factors associated with a higher risk of developing these symptoms.Secondary objectives: - To investigate the salivary…
The first aim of this study is to use an in vitro approach using patient*s derived material to accurately and rapidly predict the optimal therapeutic approach that will predict a good clinical response in individual patients. The second aim of this…
Objective1) Validate the biomarker potential of CXCL10, TNFR2, and galectin-9 in disease activity monitoring of JDM and DM.2) Determine the role of IL-18, CCL2, CCL4, CCL19, CCL27, CXCL10, CXCL13, TNFR1, TNFR2, galectin-9 and other potential…
We aim to investigate if aortic stiffness, measured by pulse wave velocity (PWV), is present in patients with DMD and whether treatment with ACEi reduces aortic stiffness.
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.
In this clinical project we aim to fill in gaps in our knowledge on muscle fiber contractility, auto-immunity and myositis: 1) How responsive is human muscle fiber contractility following standard of care immunosuppressive treatment? 2) Is the…
The primary goal of this study is to identify immunological alterations in blood, lymphoid tissue, bone marrow and muscle in IIM patients. Furthermore, our objective is to specifically profile autoreactive B lineage cells from IIM patients isolated…
Primary: To determine the contractile strength and the structure of single muscle fibers isolated from biopsies of the diaphragm and lateral abdominal muscles from mechanically-ventilated patients. Secondary: (i)To elucidate the molecular mechanisms…