358 results
To provide an extensive clinical and psychosocial characterization of IBS patients with and without psychological and/or physical comorbidities, as well as of disease-controls without IBS, but with psychological and/or physical disease, and a…
To answer the following questions; (1) What is the estimated effect size of personalized rehabilitation therapy for improving daily functioning in severely fatigued myositis patients, compared to usual care? (2) What are the societal costs of…
This study has been transitioned to CTIS with ID 2024-511707-42-00 check the CTIS register for the current data. The purpose of this study is to collect long-term follow-up safety and efficacy data on patients with SMA who were treated with OAV101…
Primary objective: To quantify the degree of respiratory muscle degeneration and dysfunction using ultrasound in patients with DMD over a wide age range; from early childhood to adults.Secondary objective: To determine the association between…
Primary Objective: to investigate the prevalence of bruxism and TMD in PD patients through objective measurements.Secondary Objectives: to identify factors associated with the presence of TMD or bruxism in a PD population.
The study aims to isolate and culture mesoangioblasts from muscle biopsies of two patient groups suffering from skeletal muscle atrophy to assess their potential for autologous muscle stem cell therapy. To relate this potential to the underlying…
This study has been transitioned to CTIS with ID 2023-510353-42-00 check the CTIS register for the current data. The purpose of this first-in-human study is to evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics…
To assess the impact of a nutritional formulation containing caprylic acid and omega 3 fatty acids on skeletal muscle function recovery from damaging exercise.
To investigate the effect of multiple sessions of whole body NMES, with or without consecutive protein intake, on muscle protein synthesis.
To evaluate the safety and efficacy of ReActiv8 for the treatment of adults with Chronic Low Back Pain and no prior spine surgery when used in conjunction with medical management.
The primary aim of the study is to compare the effects of protein versus placebo supplementation on 24 hour post-race delayed onset muscle soreness after strenuous endurance exercise performance among endurance runners.The secondary aim of the study…
Primary Objective:The primary objective of this study is to provide confirmatory data on the beneficial effect of 2.0 g/kg of Octagam 10% given every 4 weeks compared with placebo in subjects with active DM based on the percentage of responders at…
Primary Objective: To determine the effects of balance training on the neural control of standing sway in healthy younger and older adults and see if the learned balance skills are retained. Secondary Objective: To determine if balance improvements…
The aim of this study is to guide European PH-centers to become specialized centers for training in PH. This approach is in line with European PH-guidelines [12] which classified the exercise training in specialized centers with a closely monitored…
1. Inventory of the current care of boys/men with Duchenne Muscular Dystrophy in the Netherlands: To establish the extent of implementation of the international guidelines and its updates in the Netherlands and to explore the relationship between…
1). Develop a model in which the electrical activity of the diaphragm (EAdi) is used to predict the transdiaphragmatic pressure (Pdi) 2) Assess to which degree this model is accurate in estimation Pdi-derived parameters (such as work of breathing…
Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis
From p11 of C1 protocol document:1) To define the characteristics of mealworm protein ingestion on protein/digestion absorption kinetics and both whole-body and myofibrillar muscle protein synthesis after a single bout of resistance exercise in…
Primary Objective: To evaluate the effect of PFR compared to standard treatment on FI in patients after LAR, by measuring the Wexner-score and the Fecal Incontinence Quality of Life Score (FIQL-score).Secondary objective:To analyse the cost…
In this study we will assess whether the application of daily blood flow restriction during 2 weeks of bed rest will attenuate losses in skeletal muscle mass and strength. With measurements, before, during and after the bed rest period, we can…
The overarching aim of this project is to study the relation between sensitisation and functioning in patients with CLBP. The project consists of 3 studies, each with a different main objective. 1. To analyse the association between instruments…