The primary aim of the study is to compare the effects of protein versus placebo supplementation on 24 hour post-race delayed onset muscle soreness after strenuous endurance exercise performance among endurance runners.The secondary aim of the study…
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome in this study is muscle soreness at 24 hours after the
exercise event for which the visual analog scale (VAS) will be used.
Secondary outcome
Secondary outcome measures include the VAS score at 48 and 72 hours after the
event, the Short-Form Brief Pain Inventory (BPI-SF) questionnaire to examine
muscle soreness and muscle complaints and the Short-Form Brief Fatigue
Inventory (BFI-SF) to assess the level of fatigue. Moreover, in a subsample of
50% (n=208) one venous blood sample will be collected between 24 to 48 hours
post-exercise to determine the muscle damage markers CK and lactate
dehydrogenase (LDH) concentrations. In the same subsample perceived muscle
soreness measured will be measured with a strain gauge algometer.
Other important outcomes are habitual protein ingestion using a 24h recall,
protein intake on the race day and 2 days post-exercise, medical history,
rating of perceived exertion during the race, finish times, average heart rate
during the run, training status and habitual physical activity and exercise
training levels using the Short QUestionnaire to Assess Health-enhancing
physical activity (SQUASH) and whether participants performed other exercises
in the 2 days after the race.
Background summary
Most exercise recovery stra tegies for endurance type athletes solely focus on
refueling and rehydration, without taking skeletal
muscle repair and recovery into account. However, post-exercise repair and
remodeling of skeletal muscle proteins provide the
basis for training-induced adaptations that underpin increments in exercise
performance. Dietary proteins may augment muscle
repair by providing the *building blocks* (i.e. amino acids) for a positive
protein synthesis balance to induce muscle repair following
acute damage. Although many studies support the importance of sufficient
protein ingestion in relation to resistance-type exercise
for enhancing muscle mass and reducing muscle soreness, the role of protein
supplementation for muscle repair and to reduce
muscle soreness among endurance athletes has been less well studied.
Study objective
The primary aim of the study is to compare the effects of protein versus
placebo supplementation on 24 hour post-race delayed onset muscle soreness
after strenuous endurance exercise performance among endurance runners.
The secondary aim of the study is to compare the effects of protein versus
placebo supplementation on post-race muscle damage biomarker concentrations
after strenuous endurance exercise performance among endurance runners.
Study design
This double-blind randomized placebo-controlled trial will consist of 2 study
arms. The effects of 15 km running exercise on muscle soreness and muscle
damage will be examined in two groups: I) protein group (60 g protein per day
for 3 days), II) placebo group (isocaloric placebo).
Intervention
Participants will be randomly allocated to one of the two groups. Participants
will be instructed to ingest the protein or placebo supplement: 1) directly
after finishing the running event, 2) prior to sleep at the same day, 3) during
breakfast on the next three days, and 4) prior to sleep on the next two days.
Study burden and risks
The risks involved in participating in this experiment are low. Protein and
placebo supplements will be produced under Good Manufacturing Practices in
certified facilities and using approved and commercially available ingredients.
Withdrawal of a venous blood sample is associated with a <5% risk of developing
a haemorrhage, but will fully disappear within 2 weeks and is not associated
with any (functional) limitations. Furthermore, participants will be asked to
fill out questionnaires. The total burden of these measurements is, physically
as well as in time, relatively low and results in important information
necessary to answer our research question.
Philips van Leijdenlaan 15
Nijmegen 6525EX
NL
Philips van Leijdenlaan 15
Nijmegen 6525EX
NL
Listed location countries
Age
Inclusion criteria
- Between 30 and 60 years of age
- Registered for the 2018 Seven H ills Run (Zevenheuvelenloop)
- Able to understand and perform the study procedures
Exclusion criteria
- Muscle sorene ss and muscle complaints in daily life (unrelated to exercise) upon enrolment
- Type I or type II diabetes
- Allergic or sensitive for milk proteins, eggs and soybeans, or lactose intolerant.
- Having been diagnosed with intestinal diseases, which will influence the uptake of protein (i.e. active inflammatory bowel disease, Crohn*s disease)
- Having been diagnosed with renal insufficiency
- Use of statins
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL67354.072.18 |
| OMON | NL-OMON22476 |