Effect van eiwitsupplementen op spierpijn en spierschade na een hardloopwedstrijd

Rationale:

Most exercise recovery strategies for endurance athletes solely focus on refueling and rehydration, without taking skeletal muscle repair and recovery into account. However, post-exercise repair and remodeling of skeletal muscle proteins provide the basis for training-induced adaptations that underpin increments in exercise performance. Dietary proteins may augment muscle repair by providing the “building blocks” (i.e. amino acids) for a positive protein synthesis balance to induce muscle repair following acute damage. Although many studies support the importance of sufficient protein ingestion in relation to resistance-type exercise for enhancing muscle mass and reducing muscle soreness, the role of protein supplementation for muscle repair and to reduce muscle soreness among endurance athletes has been less well studied.

Objective: The primary aim of the study is to compare the effects of post-exercise protein versus placebo supplementation on delayed onset muscle soreness among endurance runners (24 hrs post race). The secondary aim of the study is to compare the effects of protein versus placebo supplementation on muscle damage among endurance runners (24-48 hrs post race).

Study design: This double-blind randomized placebo-controlled trial will consist of 2 study arms. The effects of 15 km running exercise on muscle soreness and muscle damage will be examined in two groups: I) protein group (60 g protein per day for 3 days), II) placebo group (isocaloric placebo).

Study population: The study population comprises 416 participants aged between 30-60 years and participating in the 2018 Seven Hills Run.
Intervention (if applicable): Participants will be randomly allocated to one of the two groups. Participants will be instructed to ingest the protein or placebo supplement: 1) directly after finishing the running event, 2) prior to sleep at the same day, 3) during breakfast on the next three days, and 4) prior to sleep on the next two days.

Main study parameters/endpoints: The primary outcome in this study is muscle soreness at 24 hours after the exercise event for which the visual analog scale (VAS) will be used. Secondary outcome measures include the VAS score at 48 and 72 hours after the event, the Short-Form Brief Pain Inventory (BPI-SF) questionnaire to examine muscle soreness and muscle complaints and the Short-Form Brief Fatigue Inventory (BFI-SF) to assess the level of fatigue. Moreover, in a subsample of 50% (n=208) one venous blood sample per participant will be collected within 24 to 48 hours post-exercise to determine the muscle damage markers CK and lactate dehydrogenase (LDH) concentrations. In the same subsample perceived muscle soreness measured will be measured with a strain gauge algometer. Other important outcomes are habitual protein ingestion using a 24h recall, protein intake on the race day and 2 days post-exercise, medical history, rating of perceived exertion during the race, finish times, average heart rate during the run, training status and habitual physical activity and exercise training levels using the Short QUestionnaire to Assess Health-enhancing physical activity (SQUASH) and whether participants performed other exercises in the 2 days after the race.

We hypothesize that endurance athletes receiving protein supplementation report a lower delayed onset muscle soreness score and lower muscle damage biomarker concentrations post-exercise compared to athletes receiving placebo supplementation.

24, 48, 72 hrs post-race

Protein supplement (60 g protein/ d) versus isocaloric placebo