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Fighting fatigue! An intervention to reduce fatigue.

The objective of this study is to develop, test and evaluate a psychosocial intervention for dialysis patients aimed at better coping with, and reducing fatigue (primary outcome) and thus improving the quality of life (secondary outcome).

The efficacy of the walk-bike on quality of life and exercise capacity in patients with idiopathic pulmonary fibrosis: a pilot study.

Primary objective• To assess the effect of use of a walk-bike in IPF patients for 8 weeks on health-related quality of life, measured with the St. George Respiratory Questionnaire, at baseline, week 9 and week 18, in patients with IPF.Secondary…

A randomised comparison of Eye Movement Desensitization and Reprocessing (EMDR), Narrative Exposure Therapy (KIDNET) and waiting list control in traumatized refugee children.

The study aims to answer the following research questions:1. How high/low are levels of symptomatology of depression and/or PTSD in traumatised refugee children in ASC?2. Do symptom levels decrease after a short-term trauma-focused intervention?3.…

Treatment of Chronic Idiopathic Cough (CIC) and Chronic Cough in patients with Idiopathic Pulmonary Fibrosis (IPF) with PA101.

The objectives of the study are as follows:*1. To assess the effectiveness of inhaled PA101 delivered via eFlow high efficiency nebulizer for treating chronic cough. Improvements in chronic cough will be assessed by measuring the change from…

Multiproblem Young Adults: a study on service use trajectories, neurobiological mechanisms and treatment effect in young adults with severe criminal, psychiatric and social problems.

With this integrative research project we will expand the knowledge on factors associated with problematic behavior in young adults. To elucidate why multiproblematic behavior in young adults exists in a persistent way we will explore the underlying…

e-COGRAT: The development, efficacy and implementation of *blended care* treatment in acquired brain injury-induced fatigue. First step: feasibility of e-COGRAT, a pilot study.

1) Is e-COGRAT usable within the ABI population?2) What are the patients* experiences with e-COGRAT?3) What are the therapists* experiences with e-COGRAT?4) What changes in the e-COGRAT are necessary?5) Does this pilot with e-COGRAT show a decline…

Wellbeingtherapy as a part of rehabilitation in psychotraumatreatment;A radomized controlled study of the positive effects from wellbeingtherapy during the phase of rehabilitation in psychotraumatreatment with adults

The objective of the study is to report about the effect on psychological wellbeing, post traumatic growth and relapse in PTSD symptoms by treating patients with WBT in comparisson with TAU during the rehabilitation in psychotraumatreatment.

A prospective, double-blind, placebo-controlled trial investigating the efficacy and safety of Org 25935 in relapse prevention in subjects with alcohol dependence

Primary objective- To assess the effects of Org 25935 on heavy drinking in subjects with alcohol dependence.Secondary objectives- assess the effects of Org 25935 on the amount of drinking- To assess the effects of Org 25935 on the first relapse to…

A longitudinal randomized clinical trial of participants satisfaction of two mandibular implant-retained overdentures, with ball, bar or locator attachment, in patients with severe resorption of the mandible.

Primary Objective:Is there a difference in patient satisfaction of the treatment in patients with a edentulous mandibular atrophic ridge comparing treatment with 2 dental implants and one of the three attachment types: ball-attachments, bar-…

Clozapine in Daily Life: an Experience Sampling Pilot Study

To determine whether changes in affect of patients with schizophrenia occur after starting clozapine.

A longitudinal randomized clinical trial of participants satisfaction of three or four mandibular implant-retained overdentures, with bar attachment, in patients with severe resorption of the mandible.

Primary Objective:Is there a difference in patient satisfaction of the treatment in patients with a edentulous mandibular atrophic ridge comparing treatment with 3 dental implants and a multiple bar or treatment with 4 dental implants and a…

The effectiveness of an intervention, including a very low calorie diet, cognitive behavioural therapy and maintenance contract, regarding weight and weight regain, diabetes management, cardiovasculair risk, depression and quality of life in overweight patients with type 2 diabetes mellitus, after 2 year follow-up.

In this RCT we combine cognitive behavioural therapy (CBT) with a maintenance contract and a specific diet (very low calorie diet), to obtain and maintain favourable effects on weight and risk profile over the long term.

Treatment of deafferentiation pain using EMDR (Eye Movement Desensitization and Reprocessing)
A randomised-controlled trial including patient with nerve damage in the jaw area.

At time of publication

Accesible behavioural interventions in Youth Healthcare for sleeping problems in young children.

In the Netherlands, there is no accesible evidence-based method for the prevention and treatment of sleepingproblems in young children, that can be carried out by Youth Healthcare nurses. This study will, in addition to existing knowlede about the…

The effectiveness of a health enhancing lifestyle program for people with intellectual disability and overweight.

The main objective of this study is to determine the effectiveness of a lifestyle program in enhancing the health of adults with an intellectual disability and overweight.

Randomized Olanzapine Clozapine Key study on Schizophrenia and Addiction in the Netherlands (ROCKSAN)

Primary research questions: 1. Is there a difference in effectiveness of clozapine treatment compared to olanzapine treatment in the reduction of substance use disorders of patients with schizophrenia and related psychotic disorders? 2. What is the…

The effect evaluation of a multidiscipinary treatment in children with obesity.

The main parameter of the study is evaluation and effectiveness of the treatment program on Body Mass Index (BMI) (as defined by Cole et al) compared to a standard intervention (increased physical activity and nutrient advice). Also the…

Effectiveness of cognitive and graded activity training (COGRAT) on post stroke fatigue. A multi-center study.

Therefore the present study is aimed at answering the following question: does cognitive and graded activity training (COGRAT) lead to a clinically significant reduction of subjective fatigue complaints in stroke patients, when compared with…

Long term follow up in patients with intermittent claudication randomized for supervised exercise training or endovascular revascularization

To evaluate the long-term clinical effectiveness of patients with IC randomized for supervised exercise training orendovascular revascularization.

Safety of transurethral ultrasound directed injection of autologous myoblasts, fibroblasts and collagen in patients with urinary stress incontinence

Primary objective: To confirm the safety of the use of Urocell as a treatment for stress incontinence due to intrinsic sphinctre deficiency.Secondary ojectives: - To score the quelity of life with a standardized questionnaire and to score the level…