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Fighting fatigue! An intervention to reduce fatigue.

The objective of this study is to develop, test and evaluate a psychosocial intervention for dialysis patients aimed at better coping with, and reducing fatigue (primary outcome) and thus improving the quality of life (secondary outcome).

The efficacy of the walk-bike on quality of life and exercise capacity in patients with idiopathic pulmonary fibrosis: a pilot study.

Primary objective• To assess the effect of use of a walk-bike in IPF patients for 8 weeks on health-related quality of life, measured with the St. George Respiratory Questionnaire, at baseline, week 9 and week 18, in patients with IPF.Secondary…

A randomised comparison of Eye Movement Desensitization and Reprocessing (EMDR), Narrative Exposure Therapy (KIDNET) and waiting list control in traumatized refugee children.

The study aims to answer the following research questions:1. How high/low are levels of symptomatology of depression and/or PTSD in traumatised refugee children in ASC?2. Do symptom levels decrease after a short-term trauma-focused intervention?3.…

Treatment of Chronic Idiopathic Cough (CIC) and Chronic Cough in patients with Idiopathic Pulmonary Fibrosis (IPF) with PA101.

The objectives of the study are as follows:*1. To assess the effectiveness of inhaled PA101 delivered via eFlow high efficiency nebulizer for treating chronic cough. Improvements in chronic cough will be assessed by measuring the change from…

Multiproblem Young Adults: a study on service use trajectories, neurobiological mechanisms and treatment effect in young adults with severe criminal, psychiatric and social problems.

With this integrative research project we will expand the knowledge on factors associated with problematic behavior in young adults. To elucidate why multiproblematic behavior in young adults exists in a persistent way we will explore the underlying…

e-COGRAT: The development, efficacy and implementation of *blended care* treatment in acquired brain injury-induced fatigue. First step: feasibility of e-COGRAT, a pilot study.

1) Is e-COGRAT usable within the ABI population?2) What are the patients* experiences with e-COGRAT?3) What are the therapists* experiences with e-COGRAT?4) What changes in the e-COGRAT are necessary?5) Does this pilot with e-COGRAT show a decline…

Palliative care for people with addiction and multiple problems: an explorative study of problems, needs, improvements and good examples experienced by healthcare professionals, patients and proxies.

The main question of this study is: "how is palliative care for people with addiction and multiple problems organized in the Netherlands, and which problems, needs, improvements and good examples are experienced by healthcare professionals,…

Closing the preventive care chain for overweight children: evaluation of the implementation of an integrated, locally aligned approach, enforcing primary care.

Get insight in the implementation and effectiveness of the integrated preventive care chain for overweight children in 's-Hertogenbosch. With the results we can optimize the support for overweight children and their parents. .

Physical functioning at the workplace in patients after total knee arthroplasty: a feasibility study

The primary aim of this pilot study is to demonstrate the feasibility of measuring physical functioning at the workplace among TKA patients and healthy colleagues objectively. Secondly, to get a first impression of objective physical functioning of…

Wellbeingtherapy as a part of rehabilitation in psychotraumatreatment;A radomized controlled study of the positive effects from wellbeingtherapy during the phase of rehabilitation in psychotraumatreatment with adults

The objective of the study is to report about the effect on psychological wellbeing, post traumatic growth and relapse in PTSD symptoms by treating patients with WBT in comparisson with TAU during the rehabilitation in psychotraumatreatment.

Stichting Gezondheidscentra Eindhoven (SGE) Smoking Cessation Innovation.

Our proposed randomized controlled trial is the first making this head-to-head comparison in a *real life* primary care setting in the Netherlands. The primary research question is: does a 12-week combination therapy of open label varenicline and…

A prospective, double-blind, placebo-controlled trial investigating the efficacy and safety of Org 25935 in relapse prevention in subjects with alcohol dependence

Primary objective- To assess the effects of Org 25935 on heavy drinking in subjects with alcohol dependence.Secondary objectives- assess the effects of Org 25935 on the amount of drinking- To assess the effects of Org 25935 on the first relapse to…

A longitudinal randomized clinical trial of participants satisfaction of two mandibular implant-retained overdentures, with ball, bar or locator attachment, in patients with severe resorption of the mandible.

Primary Objective:Is there a difference in patient satisfaction of the treatment in patients with a edentulous mandibular atrophic ridge comparing treatment with 2 dental implants and one of the three attachment types: ball-attachments, bar-…

Clozapine in Daily Life: an Experience Sampling Pilot Study

To determine whether changes in affect of patients with schizophrenia occur after starting clozapine.

A longitudinal randomized clinical trial of participants satisfaction of three or four mandibular implant-retained overdentures, with bar attachment, in patients with severe resorption of the mandible.

Primary Objective:Is there a difference in patient satisfaction of the treatment in patients with a edentulous mandibular atrophic ridge comparing treatment with 3 dental implants and a multiple bar or treatment with 4 dental implants and a…

Implementation of a nurse-led self-management support programme among patients with diabetes in primary care: inquiry into efficiency

Our pragmatic trial aims to integrate a cost-effective innovative care intervention in regular primary care. The intervention needs to be adapted for practice nurses to detect mental health problems in physical chronic patients and to provide,…

Trial Illness Management and Recovery (IMR)
Effects of IMR on patients with severe mental illness

The aim of this study is to examine the effectiveness of the IMR program compared to care as usual (CAU) in patients with SMI.

The effectiveness of an intervention, including a very low calorie diet, cognitive behavioural therapy and maintenance contract, regarding weight and weight regain, diabetes management, cardiovasculair risk, depression and quality of life in overweight patients with type 2 diabetes mellitus, after 2 year follow-up.

In this RCT we combine cognitive behavioural therapy (CBT) with a maintenance contract and a specific diet (very low calorie diet), to obtain and maintain favourable effects on weight and risk profile over the long term.

Management and treatment of patients with a (previous) substance dependency and/or marginally housed patients with chronic hepatitis C: a prospective observational registry

To register the feasibility of treatment with peginterferon and ribavirin for chronic hepatitis C in (previous) substance users and other difficult to treat patients within the Project Active Testing.

Treatment of deafferentiation pain using EMDR (Eye Movement Desensitization and Reprocessing)
A randomised-controlled trial including patient with nerve damage in the jaw area.

At time of publication