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A Phase 3 Multicenter, Multi-dose, Open-label Maintenance Study to Investigate the Long-term Safety and Efficacy of ZS (Sodium Zirconium Cyclosilicate), an Oral Sorbent, in Subjects with Hyperkalemia

Primary objective of this trial is to generate open-label, long-term (up to 12 months) safety and tolerability data for ZS in subjects with hyperkalaemia (S-K * 5.1 mmol/L)Secondary objectives:* To evaluate the portion of ZS-treated subjects in whom…

Determination of sodium content in sweat in critically ill hypernatremic patients.
Does Non osmotic storage of tissue sodium influence sweating and thermoregulation

To noninvasively investigate the amount and (sodium and chloride) content of sweat in hypernatremic patients in the ICU.

Diabetes and walking exercise

The primary aim of this study is to assess the impact of prolonged walking on fluid- and electrolyte balance in 32 patients with T2DM, compared with a matched group of 32 healthy control subjects, and 32 patients with T1DM, during the Nijmegen Four…

Neurocognitive functioning in school-aged cystinosis patients: general effects of chronic disease or specific deficits?

The aim of the study is to improve the quality of life of cystinosis patients. Part of it forms neuropsychological screening in order to identify specific defects in the neurocognitive development and learning abilities. The results will contribute…

Predictive factors for sarcopenia and malabsorption in high risk surgical oncological patients after cytoreductive surgery and HIPEC procedure

To investigate the predictive factors for sarcopenia in high risk surgical oncological patients undergoing a CRS + HIPEC procedure. The secondary goal is to investigate the predictive factors for malabsorption and the incidence of anastomic leakage…

Prospective, randomized, controlled, double-blind, multicentre, multinational study on the safety and efficacy of 6% Hydroxyethyl starch (HES) solution versus an electrolyte solution in patients undergoing elective abdominal surgery

To investigate non-inferiority regarding the safety of a 6% HES solution (Volulyte 6%) versus an electrolyte solution (Ionolyte) in patients undergoing elective abdominal surgery.

Validation Reseach of Medimate Miniab, Multi Lab-chip 2017

The main objective is to define the self-test performance by means of the Total Error for the Medimate Minilab 2017 for the set of parameters.

Pragmatic, prospective, randomized, controlled, double-blind, multicentre, multinational study on the safety and efficacy of a 6% Hydroxyethyl starch (HES) solution versus an electrolyte solution in trauma patients

To investigate the safety of a 6% HES solution (Volulyte 6%) versus an electrolyte solution (Ionolyte) in trauma patients.

Role of a simple lung ultrasound score in defining pulmonary edema during early fluid overload in pediatric mechanically ventilated patients

To assess whether pulmonary edema as detected by a lung ultrasound B-line score correlates with the occurrence of early fluid overload and oxygenation failure in mechanically ventilated critically ill children.