15 results
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
The aim of the study is to determine whether prenatal and current exposure to environmental chemicals is associated with developmental outcome in adolescents. We will investigate whether this exposure is associated with the thyroid hormone…
The objective is to study the effect of vagal nerve stimulation on bone turnover, lipid metabolism and inflammation.
To establish the presence of direct trans-intestinal cholesterol excretion (TICE) in humans by faecal recovery of i.v. administered 13C-cholesterol in patients with a total biliary obstruction. This is a so-called proof-of-concept study.
To study whether the lower cholesterol absorption rates of the Dahlia-2a study were due to lower bioavailability of the oral D7-cholesterol tracer.
What is the difference in fractional cholesterol absorption, measured by means of the dual isotope method, between mildly hypercholesterolemic subjects with high plasma campesterol/TC ratios compared to subjects with low plasma campesterol/TC ratios…
To estimate reference values for reverse cholesterol transport, cholesterol absorption, hepatic cholesterol excretion and direct trans-intestinal cholesterol excretion in humans.
Evaluation of the incidence of liver enzyme abnormalities and hepatic steatosis in all type 2 diabetes mellitus patients (about n=1500) treated at the outpatient clinic internal medicine of the St Lucas Andreas Hospital
What is the difference in fractional cholesterol absorption, measured by means of the dual isotope method, between mildly hypercholesterolemic subjects with high plasma campesterol levels compared to subjects with low plasma campesterol levels?
Primary Objective: What is the variation in non-cholesterol sterol levels in a large population of mildly hypercholesterolaemic, but otherwise healthy subjects?Secondary Objective: Can genetic variation in proteins involved in cholesterol…
Primary objective:To investigate the correlation between skeletal muscle phosphocreatine (PCr) on-kinetic at the beginning of exercise and CrAT protein abundance/activity in healthy young males characterized by a wide range of maximal aerobic…
The primary objectives of this study is to study the endocrine regulation of growth in preterm infants.Secondary objectives are to study the influence of the endocrine regulation and early nutritional intake on neurodevelopmental outcome, bone…
1. To adapt and optimize the MR protocol to enable multi-parametric dynamic acquisitions during 1 hour of mild-cold exposure.2. To investigate tissue dynamics of metabolic activity of the hypothalamus, BAT, and skeletal muscles, measured by dynamic…
Primary:-To identify subjects with documented history of myocardial infarction (MI) and/or percutaneous coronary intervention (PCI) and lipoprotein(a) (Lp[a]) levels >=90 mg/dL or Lp(a) >=200 nmol/LSecondary:-Evaluate the distribution…
To characterize the molecular mechanisms underlying parasympathetic regulation of adipose tissue.