74 results
Research Questions: Primary:1. Does a single night of short sleep reduce metabolic flexibility following a mixed meal challenge?2. Does a single night of short sleep alter the responsiveness of the HPA-axis?3. Are the disturbances of a single night…
The purpose of the study is to investigate wether long-term resveratrol supplementation (6 months) leads to improved insulin sensitivity (estimated by Matsuda Index) in people with overweight/obesity. In addition we will investigate effects of…
To unravel the cause(s) of the FH phenotype in patients with no mutations in well-established lipid genes (LDLR, APOB, PCSK9).
To explore the inflammatory changes of a PCSK-9 inhibitor compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus.
Hypertension is characterized by vascular remodelling and endothelial dysfunction. Sphingolipids such as ceramide and sphingosine-1-phosphate may play an important role in regulation of vascular contractility and tonus. In this study the altered…
To obtain human fibroblasts from extreme dyslipidemia patients or patients with premature atherosclerosis to study cholesterol metabolism.
To study the mechanisms underlying ectopic fat accumulation (i.e. in liver or muscle) by excess intake of added sugars in long-term obestiy in relation to insulin resistance and metabolic complications.
The purpose of the current study is to evaluate the difference in TICE in FHBL-patients as compared to unaffected controls, according to the previously developed stable isotope method with minor modifications (METC 10/092). This way we can prove the…
To set up NQplus, a longitudinal observational study on 1750 members of the sampling frame to a. build NDARD, the National Dietary Assessment Reference Databaseb. build a database to validate the LifeLines FFQc. build a database and biobank for the…
Primary Objective: - HSPG expression in liver tissue of patients with type 2 diabetes mellitus and NASH compared to liver tissue from subjects without type 2 diabetes mellitus with and without NASH. Secondary Objectives: - Correlation between HSPG…
1. Do body fatness and/or body fat distribution show a linear association withmicrovascular function in normal as well as IGT subjects?2. Is the effect of body composition on the microvasculature mediated by alteredadipokine profile, low-grade…
Aim of this study is to acquire more insight in the relation between risk factors for cardiovascular disease and type 2 diabetes and anthropometric measures such as BMI, waist circumference and body fat percentage and compare the results between the…
The objectives of the study are 1) whether ResvidaTM is capable of increasing mitochondrial content and function in healthy obese subject, 2) whether the ResvidaTM induced increase in mitochondrial content and function is accompanied by a better fat…
The purpose of the current study is to evaluate the difference in TICE in FHBL-patients as compared to unaffected controls, according to the previously developed stable isotope method with minor modifications (METC 10/092). This way we can prove the…
To investigate the frequency and the biology of the metabolic syndrome in childhood cancer survivors in order to find risk factors for cerebro- and cardiovascular diseases and to design preventive intervention strategies in indicated risk groups
We try to find a new standard within the field of ''MicroRNA'' proteins, that swim around in peoples blood and/or urine. MicroRNA's are very small proteins, that switches of genes in the cells, they are able to switch genes…
To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis
We would like to evaluate the beneficial effects of fibrate treatment on muscle mitochondrial and cardiac function in patients with NLSDM.
To examine whether resveratrol supplementation in type 2 diabetic patients improves overall and muscle-specific insulin sensitivity by affecting mitochondrial fat oxidative capacity. Furthermore, we are interested is this also affects liver and…
Based on our hypothesis that differential availability of SCFA will be beneficial effects on substrate and energymetabolism, the following objectives have been and will be addressed:- In our previous study (METC 11-3-079, NL38679.068.11) we have…