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The effect of uterine bathing on implantation in endometriosis patients undergoing IVF/ICSI: a randomized controlled pilot trial

To evaluate the effect of uterine bathing in improving the results of IVF/ICSI treatment in patients with endometriosis ASRM stage I-IV.

A Phase 1, Randomized, Blinded, Placebo-Controlled, Dose-Ranging Study of MVT-602 in Healthy Premenopausal Women

PrimarySafety and tolerability of MVT-602 following single dose subcutaneous administration in healthy premenopausal womenSecondaryPharmacokinetics (PK) and pharmacodynamics (PD) of MVT-602 following single dose subcutaneous administration

The effect of pH on human embryo development

To study the in vitro development of embryos in a pH that better resembles the pH of the uterus.

A single blind, randomized, cross-over placebo controlled dose finding study to investigate the pharmacokinetic profile of 3 doses of sublingual testosterone solution and their effect on physiological and subjective arousal in healthy, sexually functional premenopausal women.

Primary objectives:To establish the lowest effective dose using physiological and subjective measures of sexual arousal.To evaluate and compare the pharmacokinetics of testosterone and its metabolites following administration of three (3) doses (0.…

The hysteroscopic morcellator versus the bipolar resectoscope for removal of residual placental tissue: a randomized controlled trial.

To compare the HM to bipolar resectoscopy for removal of residual placental tissue in terms of efficiency and complications.

The hysteroscopic morcellator versus the bipolar resectoscope for removal of larger intrauterine polyps: a randomized controlled trial.

To compare the HM to bipolar resectoscopy for removal of large intrauterine polyps in terms of efficiency and complications.

A phase III, randomized, controlled, single-blind, multicentre, parallel arm trial to assess the efficacy and safety of Pergoveris® (follitropin alfa and lutropin alfa) and GONAL-f® (follitropin alfa) for multifollicular development as part of an assisted reproductive technology treatment cycle in poor ovarian responders, as defined by the European Society of Human Reproduction and Embryology criteria

The primary objective of the trial is to demonstrate superiority of Pergoveris® versus GONAL-f® in poorovarian response (POR) patients defined according to modified criteria set forth by the European Society of Human Reproduction and Embryology (…

A phase I, mono-center, randomized, placebo and comparator controlled, single blind, rising dose, clinical study to determine single dose pharmacokinetics, pharmacodynamics, safety and tolerability of four doses of FSH-GEX* according to adaptive design (25, 75, 150 and 300 IU) administered subcutaneously in healthy pituitary-suppressed female volunteers

- To assess the safety and (local) tolerability of test compound following single rising dose administration by subcutaneous injection- To determine FSH pharmacokinetic parameters including Cmax and AUC0-last of test compound following single rising…

A phase I, mono-center, placebo and comparator controlled, single-blind, randomized, parallel group, clinical study to determine multiple dose safety, tolerability, pharmacokinetics, and pharmacodynamics of FSH-GEX* administered subcutaneously in healthy pituitary-suppressed female volunteers

- To assess the safety and tolerability of FSH-GEX* following multiple dose administration by subcutaneous injection- To determine the pharmacokinetic profile of FSH-GEX* following multiple dose administration by subcutaneous injection- To assess…

The hysteroscopic morcellator versus the bipolar resectoscope for removal of submucous myomas: a randomized controlled trial.

To compare the HM to bipolar resectoscopy for removal of smaller type 0 and 1 myomas in terms of efficiency and complications.

A Combined Escalating Single Oral Dose and Multiple Oral Dose Trial investigating Safety, Tolerance, Pharmacokinetics and Pharmacodynamics of SCH 900479 in Healthy Postmenopausal Female Subjects

Primary:To investigate the safety and tolerability of single oral administration of study medication in healthy postmenopausal females (Part I)To investigate the general safety and tolerability of the study medication in healthy postmenopausal…

A RANDOMISED CONTROLLED TRIAL COMPARING BALLOON ENDOMETRIAL ABLATION (THERMABLATE) VERSUS BIPOLAR ENDOMETRIAL ABLATION (NOVASURE) IN THE OUTPATIENT CLINIC WITH LOCAL ANESTHESIA

The purpose of the study is to evaluate the effectiveness and acceptability of the hot fluid balloon endometrial Thermablate ablation system compared with the Bipolar RF Novasure ablation treatment performed in an outpatient setting in eliminating…

Electrosurgical bipolar vessel sealing using LigaSure versus conventional clamping and suturing for vaginal hysterectomy: a randomized controlled trial

To randomly compare the effects of vessel sealing LigaSure on the operative parameters, post-operative pain and recovery and post-operative function of the pelvic floor in vaginal hysterectomy,

A phase II, multicentre, randomised, assessor blinded, active-comparator, parallel-group dose finding trial to evaluate AS900672-Enriched versus follitropin alfa (GONAL-f) in oligo-anovulatory infertile women undergoing ovulation induction (OI)

Primary objectiveThe primary objective of this trial is to identify the optimal effective dose of AS900672-Enriched to induce ovulation in oligo-anovulatory infertile women.Secondary objectives* To demonstrate that the clinical pregnancy rate of the…

Cognitive behavioral therapy to improve quality of life after surgical treatment of women with endometriosis

The primary objective of this study is to investigate whether usual care combined with CBT improves QoL in patients undergoing surgery for endometriosis compared to usual care only. Secondary objectives are to investigate whether pain intensity,…

The hand driven hysteroscopic tissue removal system (Resectr 9Fr) versus motor driven hysteroscopic tissue removal system (Truclear) for removal of polyps: A randomized controlled trail.

Primary Objective: Comparing installation and operating time between the Truclear HM device and the Resectr HM device for removal of intrauterine large polyps.Secondary Objective(s): Comparing data on peri- and post operative complications (e.g.…

A Pilot-study to determine the (cost) effectiveness of the adhesion barrier 4DryField® PH in prevention of dysmenorrhea, abdominaal pain and niche-related problems after caesarean sections

Primary objective: to study the (cost) effectiveness of applying the 4DryField barrier on the uterine scar after a caesarean delivery, in the prevention of adhesions, niche development and related gynecological symptoms. Secondary objectives: to…

The costeffectiveness of double layer closure of the caesarean (uterine) scar in the prevention of gynaecological symptoms in relation to niche development.

Primary objective: to study the (cost) effectiveness of double layer closure of the uterine scar after a caesarean delivery, in comparison to single layer closure, in the prevention of niche development and related menstrual spotting.Secondary…