135 results
Primary objective:* To determine whether orteronel 300 mg twice daily (BID) plus prednisone 5 mg BID more effectively reduces serum testosterone levels, compared to placebo plus prednisone 5 mg BID, when administered to patients in JapanSecondary…
Influence of Injection time of DCE-MRI for prostate cancer patients with consistent kinetic parameters.
Main objective of this study is to test the safety and feasibility of MR-guided focal cryosurgery in newly diagnosed prostate cancer patients and in patients with recurrent prostate cancer after radiotherapy. Secondary objectives are: to determine…
To apply a novel blood assay to 150 patients undergoing a radical prostatectomy in order to assess whether this test can accurately identify indolent cancers and thereby prevent unnecessary treatments. To increase the accuracy of the flow cytometric…
The objective of the study (phase 2) is to evaluate the effectiveness of AMG 102 in combination with Mitoxantrone and Prednisone in previously treated subjects with castrate resistant prostate cancer.
1) To assess the antitumor activity of PHA-739358 administered as IV infusion according to two different dose schedules in metastatic HRPC patients progressing on standard docetaxel-based chemotherapy.2) To have a precise idea of the antitumor…
The primary aim of the phase I part of this trial is to establish the safety of a split dose regimen of Re-188-HEDP . The primary aim of the phase II part of this trial is to obtain insight in the efficacy of a split dose regimen of Re-188-HEDP , as…
The primary objective is to compare the sensitivity and specificity of tumour size and growth assessed with HistoScanningTM with the PRIAS parameters (PSA changes). The sensitivity and specificity of both methods will be measured with adverse biopsy…
The potential use of intraoperative, ICG based sentinel node identification, fluorescence imaging of LN*s during lymphadenectomy for prostate cancer
The primary aim of the phase I part of this study is to establish the safety profile and to determine the maximum tolerated dose of capecitabine combined with Re-188-HEDP.The primary aim of the phase II part of this study is to obtain insight in the…
The primary objective is to determine if the incorporation of Multimodality MRI including MRGB within the Prostate cancer Research International for Active Surveillance (PRIAS) study for low-risk low volume prostate cancer leads to a higher number…
To determine the diagnostic accuracy of multimodality MRI in detecting locally recurrent prostate cancer two years after treatment with external beam radiation therapy.
To objectify and quantify patients ano-rectal complaints to identify the exact pathophysiology and involved anatomic structures. Following this, irradiation techniques can be developed or modified to selectively spare the abovementioned structures,…
The following objectives have been defined for PROCABIO:1. Integration of biomarkers in an updated and improved model for the prediction of indolent prostate cancer.2. Integration of biomarkers in the development of guidelines for efficient…
To prove the diagnostic accuracy of 3T multi-modality MR imaging (high resolution T2-weighted MRI, DCE-MRI, MRSI and DWI techniques) in distinguishing carcinoma from other prostate tissue. The gold standard for distinguishing the tissue types is the…
To quantify the motion of the seminal vesicles.
The aim of this study is to get insight into bioavailability of selenium in prostate tissue and changes of gene expression profiles that might be responsible for selenium-induced chemoprevention. To meet this objective, the relationship between…
The purpose of our study is to prospectively establish in vivo in patients proof of principle for the RUNMC MR imaging-compatible robotic system designed for image-guided prostatic needle intervention.
To determine the performance characteristics (specificity, sensitivity, and positive and negative predictive values) of the PCA3 Assay using prostate biopsy as the reference method in men who are scheduled for a repeat prostate biopsy after a…
Primary ObjectiveTo establish a prospective cohort of patients undergoing radiotherapy for breast, prostate or lung cancers following local regimens and collecting standardised radiotherapy toxicity data, non genetic risk factor data and samples for…