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Is endometrial withdrawal bleeding necessary prior to ovulation induction with clomiphene citrate?;A randomized controlled trial and feasibility study

To evaluate the effects of withholding progesterone-induced endometrial withdrawal bleeding before ovulation induction on the time to pregnancy and the ongoing pregnancy rate.

The effect of uterine bathing on implantation in endometriosis patients undergoing IVF/ICSI: a randomized controlled pilot trial

To evaluate the effect of uterine bathing in improving the results of IVF/ICSI treatment in patients with endometriosis ASRM stage I-IV.

Predicting ovarian response in artificial insemination with low stimulation

This large prospective multi-center cohort study aims to identify patient*s characteristics that significantly influence ovarian response to mild stimulation with a fixed dose of 75 IU recombinant FSH

A Phase 1, Randomized, Blinded, Placebo-Controlled, Dose-Ranging Study of MVT-602 in Healthy Premenopausal Women

PrimarySafety and tolerability of MVT-602 following single dose subcutaneous administration in healthy premenopausal womenSecondaryPharmacokinetics (PK) and pharmacodynamics (PD) of MVT-602 following single dose subcutaneous administration

The effect of pH on human embryo development

To study the in vitro development of embryos in a pH that better resembles the pH of the uterus.

A single blind, randomized, cross-over placebo controlled dose finding study to investigate the pharmacokinetic profile of 3 doses of sublingual testosterone solution and their effect on physiological and subjective arousal in healthy, sexually functional premenopausal women.

Primary objectives:To establish the lowest effective dose using physiological and subjective measures of sexual arousal.To evaluate and compare the pharmacokinetics of testosterone and its metabolites following administration of three (3) doses (0.…

Early versus late insemination relative to ovulation in subfertile couples: a trial-based cost-effectiveness study.

The main objective is to determine the effectiveness of IUI-MOS, comparing the ongoing pregnancy rate of a treatment strategy comprising a maximum of four cycles of IUI-MOS when performing IUI 32-36 hours after triggering of ovulation by hCG (*late…

Cost-effectiveness of IUI, IVF and ICSI for male subfertility. The MAle Subfertility Therapy Effectiveness Rcts (MASTER).

In one third of subfertile couples male subfertility is diagnosed. Current treatments for male subfertility, IUI, IVF and ICSI, have,despite their widespread use, not been compared on their cost-effectiveness. The primary aim of this project is to…

THL study: A multicenter trial comparing the cost-effectiveness of transvaginal hydrolaparoscopy and hysterosalpingography in the work-up for subfertility.

Objectives: The purpose of this study is to assess the costs and effects of THL compared to HSG in a large randomized controlled trial.

A phase I, mono-center, randomized, placebo and comparator controlled, single blind, rising dose, clinical study to determine single dose pharmacokinetics, pharmacodynamics, safety and tolerability of four doses of FSH-GEX* according to adaptive design (25, 75, 150 and 300 IU) administered subcutaneously in healthy pituitary-suppressed female volunteers

- To assess the safety and (local) tolerability of test compound following single rising dose administration by subcutaneous injection- To determine FSH pharmacokinetic parameters including Cmax and AUC0-last of test compound following single rising…

A rising multiple dose study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered SCH 900389 in healthy females (P07036)

To investigate the safety and tolerability of the test compoundTo study how the test compound is absorbed, broken-down and excreted by the bodyTo study the effect of the test compound on the functioning of the body, particularly the ovaries and sex…

Detection of Chlamydia trachomatis antibodies in vaginal swabs as an intermediate marker for PID and tubal pathology * pilot study

To asess whether the Chlamydia Antibody Test (CAT), used to determine the presence of antichlamydia IgG antibodies in serum for diagnostics in the fertility clinic, can serve as an intermediate marker for PID/tubal pathology caused by Chlamydia.

A double blind, randomized, cross-over placebo controlled study to investigate the efficacy of sublingual testosterone solution on physiological and subjective arousal in healthy, sexually dysfunctional premenopausal women.

Primary objectives:To confirm the lack of effect of 0.5 mg sublingual testosterone on physiological and subjective measures of sexual arousal in women with HSDD. Secondary objective:To confirm the lack of effect of 0.5 mg sublingual testosterone on…

Patient-controlled remifentanil analgesia (PCA) during oocyte retrieval for IVF/ICSI procedures

The main objective of this open-label, randomized clinical trial is to asses whether patient-controlled analgesia with remifentanil is more efficious and equally safe as pethidine as analgesic strategy during ultrasound-guided transvaginal oocyte…

Chlamydia trachomatis antibody test in vaginal swabs as an intermediate marker for PID and tubal pathology - pilot study in fertility clinics

We will investigate whether Chlamydia IgG antibody presence and titers in vaginal swabs (mucosa-CAT) are comparable to antibodies found in serum (serum-CAT), and as such could serve as a marker for a past Chlamydia infection with an enhanced risk of…

The influence of laparoscopic hernia repair on male fertility

This study is a pilot study to examine the presence of antisperm antibodies after laparoscopic groin hernia repair in men. The hypothesis of this pilot study is: After laparoscopic groin hernia repair with a mesh, antisperm antibodies can be…

A phase I, mono-center, placebo and comparator controlled, single-blind, randomized, parallel group, clinical study to determine multiple dose safety, tolerability, pharmacokinetics, and pharmacodynamics of FSH-GEX* administered subcutaneously in healthy pituitary-suppressed female volunteers

- To assess the safety and tolerability of FSH-GEX* following multiple dose administration by subcutaneous injection- To determine the pharmacokinetic profile of FSH-GEX* following multiple dose administration by subcutaneous injection- To assess…

HSG versus HyFoSy: is there a difference in VAS-painscores between these two tubal patency tests?

To determine wether a HyFoSy is a less painful procedure compared to a HSG examination for tubal patency testing

Validation of the Dutch version of the International Index of Erectile Function (IIEF) in patients with erectile dysfunction and controls

The present study is designed to validate the Dutch IIEF. The psychometric properties of the Dutch version of the IIEF will be investigated.

Cryo-thawed embryo transfer: natural versus artificial cycle. A non inferiority trial.

To compare live birth rates among patients receiving cryo thawed embryo transfer after endometrial preparation with estrogen/progesterone substitution and patients receiving cryo thawed embryo transfer in a natural cycle.