86 results
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
The primary objective is to compare the effectiveness of ambroxol versus placebo on the MDS-UPDRS part III motor sub-score in the *practically defined OFF-medication state* in patients with moderate PD, carrying a GBA mutation. The hypothesis is…
The objectives of this study are: 1. to identify new genetic variants causing or predisposing to PD; 2. to characterize the clinical phenotype in PD associated to specific genetic variants; 3. to investigate the molecular mechanisms of PD in…
Because experimental evidence suggested the possibility to measure paratonia through muscle activity, the primary aim of this study is to develop an objective non-invasive tool based on surface electromyography (sEMG) to quantify the presence and…
Test whether a mindfulness-based cognitive therapy intervention (MBCT) improves psychological distress, clinical symptoms, slows neurodegeneration, and/or enhances neuroplasticity in PD.
To sequence the GBA1 gene in Parkinson*s disease patients to identify possible participants for a possible future phase 1 trial. The gene will be described as wildtype (WT) or containing a mutation (GBA+); with record of the specific mutation. To…
This study has been transitioned to CTIS with ID 2024-516321-31-00 check the CTIS register for the current data. The purpose of this study is to measure clinical efficacy on muscle strength and function, safety, and tolerability of NMD670 compared…
In this project we aim to evaluate whether a non-pharmacological and tailored intervention targeting anxiety- and stress-related FOG in people with PD is effective to reduce the impact of anxiety and stress on FOG. Specifically, we aim to study: (1…
To design and test a personalized biopsychosocial rehabilitation treatment that aims to restore daily life functioning and QoL in persons with SCI and chronic pain.
To investigate if a personalized multimodal physical therapy program compared to ACDF surgical treatment is non-inferior over a 12-month period and cost-effective in patients with painful cervical radiculopathy who have an indication for…
Investigate the effect of hilotherapy on the severity of CIPN and nail toxicity, and its influence on treatment management and quality of life in patients with breast cancer during, and three and six months after treatment with Paclitaxel.
The main goal of this study is to determine motor, cognitive, behavioral, executive, and language functioning of children with PAIS at school age. Furthermore, we will analyze the effect of PAIS on brain growth, development, and connectivity using…
The primary objective is to determine the feasibility of a remote intervention study to promote physical activity in people with iRBD. The secondary objectives are to determine the longitudinal effect of an exercise intervention in people with iRBD…
The primary objective of this trial is to assess the efficacy of immediate CAS among patients with acute ischemic stroke treated with EVT and a severe ipsilateral proximal carotid artery stenosis (>50%) or occlusion and compare this with the…
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.
This study has been transitioned to CTIS with ID 2023-508284-77-00 check the CTIS register for the current data. The purpose of this study is to evaluate the safety and efficacy of ALXN1720 for the treatment of gMG in adults with autoantibodies…
To assess to what extent a 12 weeks intervention consisting of Neuromuscular electrical stimulation (NMES) to the quadriceps muscles may change cognitive function and blood levels of the biomarker Brain-derived neurotrophic factor (BDNF) in persons…
The primary objective is to determine if physical fatigability is present in infantile and young adult patients with FSHD.The secondary objectives are to determine if there is an association between fatigability ando Disease severityo Muscle…
Primary Objective: To identify disease (Parkinson*s disease) specific alterations in neural control of breathing by using respiratory neurophysiological techniques.
Part 1: Assess the natural disease course of three congenital myopathies during 24 months. This will enable us to obtain a detailed assessment of the phenotype and genotype, evaluate and optimize the current care, determine the rate of disease…