22 results
The primary objective is to test whether rhythmic somatosensory input (vibrotactile stimulation at tremor frequency) reduces tremor power of Parkinson*s tremor, as compared to other vibrotactile stimulation settings (continuous stimulation,…
To investigate whether treatment of dystonia causing varus tilt of the hindfoot in Parkinson*s disease is more effective when botulinum toxin type A is combined with complementary functional gait training compared to botulinum toxin type A treatment…
We here validate the algorithms for movement analysis that were developed previously in healthy participants (METc 2019.542; regarding quantitative aspects of movement) and that were derived from a review of the literature (regarding qualitative…
Primary Objectives* To investigate the intra-variability (day-to-day) of glucocerebrosidase pathway biomarkers in HV, PD-GBA+ and PD-GBA-Secondary Objectives* To investigate the intra-variability (within-day) of glucocerebrosidase pathway biomarkers…
The main objective of PD0053 is to provide POC for the efficacy of the ASYN misfolding inhibitor UCB0599 in reducing disease progression in study participants with early-stage PD, and to instruct later stage development. The ultimate goal is to…
The primary objective of this study is to compare cholinergic innervation of the cerebral cortex of GBA-PD and non-GBA-PD patients, using [18]FEOBV PET imaging of the brain.
The primary objective of this study is to establish a cut-off score on the MoCA, with a high, preferably 100%, sensitivity and reasonable specificity (>70%), in order to identify patients who will fail the CBR assessment, being unfit to drive…
Primary objectives: 1. Assess the feasibility of FMT in PD patients.2. Assess the safety of FMT in PD patients. Secondary objectives:1. Explore whether FMT leads to alterations in motor complications (fluctuations or dyskinesias) and PD symptoms in…
The aim of this study is to assess the safety and the potential efficacy of personalized Local Field Potential (LFP)-based adaptive Deep Brain Stimulation (aDBS), using the implantable pulse generator (IPG), «AlphaDBS» System, in Parkinson*s Disease…
To identify which speech control mechanisms in PD patients are impaired and to what extent by comparing PD patients in various stages of the disease and adult control speakers.
To evaluate the usability of vibrating socks as a home-based tactile cueing device in PD.
The primary objective of the proposed research is to investigate in patients with PDD the efficacy of STN-DBS with best oral medical treatment (DBS-group) for disabling motor symptoms during off-drug phase compared to best oral medical treatment…
We aim to develop and validate algorithms to quantify and track physical capacity and physical activity to be used as clinical trial endpoints for the development of pharmacological and non-pharmacological interventions for participants with COPD…
The goal of this study is to examine the feasibility of a home-based VR intervention to improve upper limb functionality in patients with CP. Primary research question: 1. Is VR-based gaming a feasible method to provide a rehabilitation intervention…
- To evaluate efficacy of NBI-827104 in subjects with ET - To evaluate safety and tolerability of NBI-827104 in subjects with ET- To evaluate pharmacokinetics of NBI-827104 and metabolite (if quantified) for each treatment in subjects with ET
Primary objective: To evaluate the role of existing and novel quantitative biomarkers in understanding the heterogeneity in the Parkinson*s phenotype (i.e. rate of progression, cognitive and neuropsychiatric impairment and motor dysfunction) and…
The purpose of the study is to demonstrate the safety and effectiveness of adaptive DBS (aDBS) for Parkinson*s disease.
The primary aim of this research is:- To investigate the effect of the STIL orthosis on the tremor severity and amplitude in patients with forearm tremor.Secondary goals of this research are:- Assess patient satisfaction with orthosis efficacy and…
This is a medical-scientific research study. The purpose of the study is to investigate the effect of multiple doses of the study compound BIA 28-6156 on the pharmacokinetics of the drugs levodopa-carbidopa (Group 1) and levodopa-benserazide (Group…
The primary objective of this study is to assess the pharmacokinetics and the effect of food on the pharmacokinetics of the YTX-7739 tablet formulation following single oral doses of 30 mg in HVs and to compare the relative bioavailability of the…