63 results
Our primary objective is to compare neuroimaging markers on a 3T MRI-scan with the MRI-scans that were performed during TRACK-HD in 2008-2011. We will assess the following neuroimaging markers, starting with the most important marker: 1. Structural…
To develop a FOG prediction algorithm under free-living conditions, and to test evaluate the use of the Parkinson*s Vibrating socks under the same conditions
To determine whether the ClinRO and PRO are valid and reliable measures for use in intervention trials, specifically:1. Evaluate the reliability and validity of the proposed ClinRO protocol to assess freezing of gait in individuals living with…
The primary objective is to determine whether there is a difference in the capability of the patients to successfully follow the instructions of both the Levodopa Cyclops* and the INBRIJA® inhaler during an off episode, based on the instruction…
Primary Objective- Evaluate longitudinal intra-individual and inter-individual variability of PBMC biomarkers in healthy participants:o LRRK2 protein (pg/mL)o total protein (ug/mL)o pS935 LRRK2/total LRRK2 peptide ratioo pRab10/Rab10 peptide ratio…
Primary objective: Identify feasibility of basal-ganglia regions as NF targets in PD patients Secondary objective: Document short-term changes in brain resting-state activation
Primary objective: To evaluate the role of existing and novel quantitative biomarkers in understanding the heterogeneity in the Parkinson*s phenotype (i.e. rate of progression, cognitive and neuropsychiatric impairment and motor dysfunction) and…
Primary objective:- To identify (a combined set of) clinical and non-clinical markers most sensitive to disease progression in Dtuch SCA7 mutation carriers.Secondary objectives:- To quantify the annual change in disease-relevant clinical scales and…
Primary Objective: To determine different familial features (demographical, clinical, neurophysiological) in essential tremor families and subsequently clustering these features into subtypes of familial essential tremor. Secondary Objective(s): To…
Our primary objectives are to study: 1) differences in the brain*s sensitivity to the effects of light on emotional processing in people with PD and people with depressive symptoms compared with healthy controls 2) whether different spectrum of…
The main objectives of this study are to acquire EEG, ECG and motion data from 15 PD patients with FOG for the algorithm development to online detect and predict FOG, and test the performance of developed algorithm in 15 PD patients with FOG. We…
The present study aims at examining the effects of DBS on speaking. We will test participants performing a verbal fluency task but also producing spontaneous language and performing a language task that is dependent on a brain area targeted by DBS.
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene carriers, compared to more classic medication prescribing parameters (such as age and comorbidities) on negative medication effects of HD-…
Primary Objectives• Characterize day-to-day, within-day, intra-individual and inter-individual variability of GCase activity in healthy participants and patients with Parkinson*s disease with a GBA1 mutation.Secondary Objectives• Assess variability…
The goal of the current study is to evaluate both the feasibility and validity of the Corival ALT prototype for exercise testing in patients with lower limb deficits.
Primary Objective: To establish whether it is feasible to oppose slowness caused by gait impairments deriving from Parkinson*s disease effectively by using a tactile-based cueing device. Secondary Objective(s): To establish if the device influences…
* Genotyping of the full GBA1 gene in people with Parkinson*s Disease, assessed as wildtype (GBA-) or containing a mutation (GBA+); the specific mutation will be recorded as well. * Assessing the presence of 7 known PD-causing mutations in the LRRK2…
To evaluate the validity of the peak frequency values and the amplitude at the peak frequency obtained from power spectral densities from the consumer product accelerometers and the laboratory-grade accelerometer following simultaneous tremor…
In preparation for future clinical studies using LRRK2 kinase inhibitors currently in development, the current study aims to characterize several potential pharmacodynamic markers of LRRK2 kinase inhibition and patient stratification. In particular…
* To determine the relationship between phenotypic and genetic characteristics of GBA-PD patients. Phenotypic characteristics will be obtained by patient dossier review. Genetic characteristics comprise of the GBA1 gene and a panel of SNPs,…