13 results
The aim of this study is to investigate the effects of DMF (Tecfidera) on the association between fatigue and fatigability measures in pwRRMS starting with DMF medication.
1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.
Primary objective:* To analyze the association between single nucleotide polymorphisms (SNP) markers and treatment response. Treatment response is based on the Expanded Disability Status Scale (EDSS) progression and relapse outcomes over the first 2…
Primary objective: To assess the efficacy of Vigantol oil versus placebo as add-on therapy in subjects with relapsing-RemittingMultiple sclerosis receiving treatment with Rebif.Secondary objective:To assess changes on clinical parametersto assess…
To quantify changes in range of motion (RoM) and muscle strain of the shoulder in hemi paretic stroke survivors compared to healthy controls in order to identify potential contracted or paretic muscles.
The overall objective of this trial is to provide additional data on the factors influencing IFN-beta response.Primary· To analyze the association between single nucleotide polymorphisms (SNP) markers and Rebif and Copaxone treatment response.…
The objective of the study is to estimate the prevalence of anti-JCV antibodies in MS patients,including the following criteria:* Age* Gender* Race* Country of birth and the duration of residence* Current country of residence and the duration of…
The NEURONED-MS cohort study aims to facilitate prospective observational research in the field of multiple sclerosis (MS). This cohort will serve as the central part of several projects that will be organized to address various issues including:1.…
1. To measure clinical outcome of patients with an autoimmune encephalitis longitudinally.2. To evaluate existing PROMS, developed for other (neurological) disease, for patients with an autoimmune encephalitis.3. To develop and validate disease-…
Recent neuroimaging research identified different pathways of how distraction is processed in WM, showing involvement of the lateral prefrontal cortex and striatum (15,21,22). It has been described that if a combined demand of WM and distraction is…
The primary objective is to investigate the effect of 12 weeks of supplementation with 3.5g/day of rumenic acid on episodic memory in older men and women at risk of cognitive impairment. Secondary objectives include working memory, attention,…
The main aim of this study is to examine predictors of (changes in) employment status and work absenteeism in relapsing-remitting MS patients and subjects without a chronic disease over a period of three years
We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…