376 results
The primary objective of this randomized trial is to determine whether patients experiencing an AIS due to an isolated medium vessel occlusion have superior functional outcome (measured with the mRS at 90 days) when treated with EVT plus BMT…
1. To study safety, feasibility and technical effectiveness of minimally-invasive endoscopy-guided surgery for treatment of supratentorial ICH; 2. To estimate the potential effect of minimally-invasive endoscopy-guided surgery on functional outcome…
Primary Objective: To further characterize, develop and validate assays for candidate protein biomarkers for the diagnosis of CAA.Secondary Objective(s): To correlate the novel neurochemical biomarkers with each other and with measures of cognitive…
The purpose of this study was to demonstrate that the PP can be improved in chronic stroke survivors using a newly developed, intensive training. The effect of the new training on the PP, walking velocity and mobility at home will be determined.…
We aim to study what the mean change in graft flow rate is when the cardiac output is increased with 10% and what the mean change in graft flow rate is, when the blood pressure is increased with 10% to enable further research to establish whether an…
This study will provide reference values for the (relative) aerobic load of daily activities for people after stroke. Furthermore, it will assess the impact of relative aerobic load on daily life activity levels for people after stroke.
We hypothesize that intracranial vessel wall atheromas are an important underlying cause of obstruction of (one of the) artery(ies) of the anterior cerebral circulation. To test our hypothesis we will perform high resolution intracranial vessel wall…
The main objective of this effectiveness study is to test if intensive control (SBP *120 mmHg) decreases cerebral blood flow velocity compared to conventional targets (SBP<140-150 mmHg) in patients with CSVD and hypertension. Secondary…
The 4D-EEG study aims to elucidate the underlying mechanisms of upper limb functional recovery using high density portableEEG (electroencephalography) methodology as well as clinical measures of motor function. The following questions are addressed:…
The primary objective of the current study is to compare the presence or absence of arterial vessel wall abnormalities in the intracranial posterior circulation in patients with TIA or ischemic stroke with those of healthy controls using 7.0 tesla…
1. To investigate the size of the HCHWA-D population by identifying all (possible) mutation carriers and their relatives. 2. Study the genealogy and natural disease history of these carriers.3. Get insight in possible genetic, environmental and…
Primary objective* To evaluate the efficacy of IAT in addition to BMM compaed to BMM alone in terms of favourable outcome at 90 days, defined as a modified Rankin score of 0-3, in patients with an acute ischemic stroke caused by basilar artery…
Primary objective is to investigate whether secondary deterioration after acute stroke is associated with CSD, infraslow activity, or epileptiform activity. Secondary objectives are (1) to assess the feasibility of continuous full-band EEG to…
The main aim of this proof-of-principle project is to explore whether 1) standardized conditions (physical tasks, cognitive tasks and a combination of both) differing in task difficulty are associated with distinct physiological responses…
Primary Objectives: - To determine which technique is most optimal for measuring vascular reactivity in CADASIL patientsSecondary Objectives: - To study CADASIL disease progression over a 17- year time frame - To determine the correlation between…
Primary Objective: To study arterial vessel wall abnormalities of the intracranial vessels (circle of Willis and its main branches and the moyamoya vessels) in patients with MMV in comparison with age- and sex-matched subjects without known…
The objective is to investigate how dementia affects processing of pain. More precisely, we aim to investigate how dementia-related neurodegeneration (occurring in Alzheimer disease (AD), frontotemporal dementia (FTD) and vascular dementia (VD))…
Primary Objective: To assess the difference in prevalence of pituitary dysfunction between patients with and patients without fatigue after ischemic stroke. Secondary Objectives: 1. To assess the time course of pituitary dysfunction after ischemic…
The main research question is to compare the diagnostic accuracy of 7T MRI for cerebral vasculitis, with the standard diagnostic practice (SDP). The true nature of the disease will be assessed for all patients at the end of the study by re-…
For the reliability part, our objective to have an initial understanding of the validity of the DynMetrics measurement system when compared to the Vicon system (gold standard). For the usability part, our objective is to quantify the usability of…