212 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
Objective 1: To prospectively evaluate the utility of C-FLOW monitor to examine status of regional CBF and reperfusion in patients presenting with acute anterior circulation ischemic stroke syndrome. Objective 2: To assess the feasibility,…
This protocol is the next step in development of a reproducible technique for the quantification of CBF using simultaneous ultrasound at the internal carotid artery. We hypothesize that simultaneous measurement of the contrast signal in the internal…
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
To ascertain the hypothesis that T-cell inflammation in the vascular wall of an unruptured intracranial aneurysm can be accurately detected with 18F-IL2 PET (proof-of-concept).
Explore difference in perforating artery pulsatility index between two patients groups with small vessel disease (history of lacunar infarct and deeply located haemorrhage) and healthy controls.
The overall aims of the proposed project are 1) to establish biomarkers for identification of the underlying vascular disease in patients with ICH and 2) to characterize whether disruption of the blood-brain barrier, a key factor in secondary brain…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT reconstructed with IR lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared…
Main study objective of this study is:To evaluate whether the 320-detector volumetric CT technology can replace carotid duplex scanning and TEE in the diagnostic workup in TIA/IS patients. Specific aims of this main study objective are:1. To assess…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
To assess the sensitivity and negative predictive values of D-dimer- and FXIII activation peptide (AP-FXIII) values in order to exclude to exclude CVT in patients with clinical suspicion of CVT.
Determining the diagnostic value of CTA in patients with acute headache and normal neurological examination and head CT by performing a prospective study. Charting patient characteristics in order to more purposefully apply the CTA and avoid…
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
[1] To develop robust assays for quantification of novel CSF/blood biomarkers of CAA.[2] To determine the contribution of CAA to cognitive decline in dementia and ICH patients, using CAA-specific biomarkers
In this study we aim to investigate the presence of CAN in diabetic patients scheduled for elective major abdominal and thoracic surgery and its relation with perioperative hemodynamic changes.
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
Primary: to study the frequency and characteristics of fatigue and cognitive disorders after minor stroke. Secondary: to gain more insight in the aetiology of post-stroke fatigue and evaluate the impact of post-stroke fatigue on personal and social…
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
To further investigate the pathogenesis of DCI and its relation to gender, decreased fibrinolysis, increased coagulation, and hormonal factors in order to eventually pave the way for new treatment options.