23 results
[1] To develop robust assays for quantification of novel CSF/blood biomarkers of CAA.[2] To determine the contribution of CAA to cognitive decline in dementia and ICH patients, using CAA-specific biomarkers
This study aims to investigate the biological efficacy and safety of eculizumab in patients with aneurysmal SAH.
To determine the diagnostic accuracy of dry electrode cap EEG for diagnosis of LVO-a, when performed by paramedics in the ambulance in patients with a suspected AIS.
The overall aim of this study is to investigate clinical risk factors and MR markers that affect disease progression to gain more insight in targets for prevention and therapy and to better inform patients on prognosis.
The primary objective of this study is to evaluate whether SAH patients at risk of developing DCI show a distinguished platelet RNA profile compared to patients without DCI. Secundary objective; to evaluate whether platelet RNA analyses can predict…
To follow up presymptomatic and symptomatic profiles including (early) disease stages and (early) biomarkers of disease progression and to elucidate pathophysiological mechanisms, we will investigate HCHWA-D patients at different ages (both…
Our primary objective is to test temporal microRNA profiles in patients presented by the emergency services to the emergency room with a suspicion of acute (i.e. <6 hours) ischemic stroke
The overall aim of this study is to assess WML and associated existing and novel SVD imaging markers to dissect the pathophysiological mechanisms underlying WML in young to middle aged women at risk for future cardiovascular disease. We aim to…
This study has been transitioned to CTIS with ID 2024-514927-40-02 check the CTIS register for the current data. To evaluate the efficacy of TXA to prevent surgery for cSDH
The main objective will be to investigate whether treatment with nVNS on top of best medical practice in acute ischemic stroke patients results in smaller infarct volumes compared with the infarct volumes of patients not treated with nVNS.
The primary objective of this proof of concept study is to test the feasibility of using the gamma-prototype of the lower limb exoskeleton XoSoft during locomotion-tasks related to daily life in stroke and iSCI patients in a controlled environment.…
To investigate if conventional tDCS can be improved by using a new electrode configuration. To find a relation between ongoing EEG and MEP magnitude. To investigate the effect of tDCS on cortical excitability (measured with TMS), brain activity (…
HypothesisWe hypothesize that a CTA of the heart and entire aortic arch, performed in the acute phase (defined as within window for reperfusion therapy through thrombolysis or thrombectomy) in patients with acute ischemic stroke, is superior to…
1. To study safety, feasibility and technical effectiveness of minimally-invasive endoscopy-guided surgery for treatment of supratentorial ICH; 2. To estimate the potential effect of minimally-invasive endoscopy-guided surgery on functional outcome…
Primary Objective: To further characterize, develop and validate assays for candidate protein biomarkers for the diagnosis of CAA.Secondary Objective(s): To correlate the novel neurochemical biomarkers with each other and with measures of cognitive…
The purpose of this study was to demonstrate that the PP can be improved in chronic stroke survivors using a newly developed, intensive training. The effect of the new training on the PP, walking velocity and mobility at home will be determined.…
We aim to study what the mean change in graft flow rate is when the cardiac output is increased with 10% and what the mean change in graft flow rate is, when the blood pressure is increased with 10% to enable further research to establish whether an…
This study will provide reference values for the (relative) aerobic load of daily activities for people after stroke. Furthermore, it will assess the impact of relative aerobic load on daily life activity levels for people after stroke.
For the reliability part, our objective to have an initial understanding of the validity of the DynMetrics measurement system when compared to the Vicon system (gold standard). For the usability part, our objective is to quantify the usability of…
1. To investigate the feasibility of controlling an arm- and hand support system with EMG, voice or wink control.2. To assess usability of the arm and hand support controlled by EMG, voice or wink.3. To investigate the possibility to distinguish…