453 results
1) To identify clinical and imaging predictors of recurrent stroke; 2) To improve early detection of small volume stroke with admission computed tomography perfusion (CTP) in patients with suspected acute ischemic stroke with small volume stroke or…
To investigate if conventional tDCS can be improved by using a new electrode configuration. To find a relation between ongoing EEG and MEP magnitude. To investigate the effect of tDCS on cortical excitability (measured with TMS), brain activity (…
To develop a feasible assessment protocol to quantify the impaired upper extremity function in terms of muscle weakness, spasticity, synergy and viscoelastic properties around the elbow.To evaluate the reliability (test-retest, measurement error)…
Primary Objective: to obtain reliable estimates of the rates of vascular death and non-fatal stroke in patients with atrial fibrillation and a recent anticoagulation-associated ICH who are treated with apixaban versus those who are treated with APDs…
The primary objective of this study is to compare the effect of gait training on gait capacity (stepping performance, gait adaptability and dynamic balance) before and after surgical correction of post-stroke foot deformity.
Objective and Research QuestionsTo identify predictors of brain outcomes in HHT patients, we propose to leverage our multicenter network of HHT Centers to characterize comprehensive brain outcomes.Study Aims:Aim 1: We hypothesize that the presence…
The aims of the present study are (1) to assess the immediate effect of a restraining force during treadmill walking on propulsion, (2) to assess what strategy stroke patients use to increase their propulsive force and (3) to assess if stroke…
Does performance on a fatiguing dual task task in patients with FSM decline more compared to patients with AIS? What are the differences in cognitive functioning and motor fatigue between FSM, AIS and healthy controls? What is the relation between…
The primary objective is to evaluate whether the concentration of six biomarkers (proteins) in SDH are related to the time of incidence of TBI. The secondary objective is to evaluate whether the fractions of the Hb-derivatives in SDH are related to…
Primary objective:To determine BBB integrity and the interplay with microvessel function including PVS and CVR response to CO2 breathing challenge in sporadic and monogenic presentations of human SVDs.Secondary objective:To determine the…
The primary objective is generation of functional neuronal networks from induced pluripotent stem cells (iPSCs) derived from patients with ischemic stroke. The secondary objectives are to measure neuronal network responses to simulated cerebral…
Primary objective: Determine for different control algorithms and robotic modules whether the algorithm and/or robotic module is effective in providing the patient with the required support and measure bringing about the desired changes in the…
The primary objective of this research programme is to develop a new functional architecture of the visual brain based on two concepts: the methodology to establish necessity and the theoretical framework of cortical networks. In addition, this…
The main objective of this study is to explore the accuracy of sCTA and ceMRA compared to DSA in the diagnosis of complete aneurysm occlusion in patients treated with a FD stent. In addition, we will look at accuracy of sCTA and ceMRA in…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with symptomatic SVDs, relative to controlsSecondary Objective(s): To establish how microvascular function relates to:• parenchymal lesion…
Primary objective: To assess the effect of transdermal GTN, started within 3 hours of symptom onset in the prehospital setting, on functional outcome at 90 days in patients with acute ischaemic stroke or intracerebral haemorrhage.Secondary…
The primary objective of this randomized controlled trial is to determine whether decompressive surgery and best medical treatment in patients with spontaneous ICH will improve outcome compared to best medical treatment only. Secondary objectives…
HypothesisWe hypothesize that a CTA of the heart and entire aortic arch, performed in the acute phase (defined as within window for reperfusion therapy through thrombolysis or thrombectomy) in patients with acute ischemic stroke, is superior to…
To explore the effect of single versus repeated preconditioning on circulating blood factors (i.e. metabolomics analysis) as a likely mechanism in patients with cSVD. Secondly, we explore whether the effects of single versus repeated preconditioning…
In oral FXa inhibitor-treated patients with acute intracranial bleeding, the objectives of this study are as follows:Primary Efficacy Objective:• To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…