45 results
The primary objective is to assess neuropsychological function in X-ALD patients without active cerebral demyelinating disease. Data of minors will be compared to matched healthy controls. Data of adults will be compared to reference values. The…
To explore the safety, tolerability and the pharmacokinetic profile of 2-IB when given on top of therapeutic hypothermia.
To assess fidelity (quality), dose delivered (completeness), dose received (exposure and satisfaction), recruitment and context of two newly developed upper limb home-based training programs, i.e. one based on implicit strategies and one based on…
The primary objective is to study if quantitative (3- and 7-Tesla) MRI protocols (MRI perfusion, diffusion tensor imaging (DTI), and chemical shift imaging (CSI)) are able to detect phenotype conversion earlier than conventional MRI. Results will be…
We aim to conduct a five year follow-up amongst the X-ALD carriers and assess their current symptomatic and biochemical status. This data will provide new insights in the progression of the disease in carriers. Moreover we would like to validate a…
1. Normalization of the abnormal serum TH parameters and thereby improving the clinical condition of the AHDS patients2. Observation of changes in cognitive and motor function.
The primary objective of this trial is to determine whether different types of anaesthesia [regional versus general] given to infants undergoing inguinal hernia repair result in equivalent neurodevelopmental outcomes. Secondary objectives are to…
- To assess the burden of disease of congenital CMV infection in the Netherlands at the age of 5 to 6 years through the assessment of the occurrence of sensorineural hearing loss due to congenital CMV infection.- To establish the burden of disease…
To evaluate the long-term effects of early intervention in high-risk infants on the basis of the VIP-project.
To increase to knowledge of how adults with OBPL function, this research will be done with de next researchquestion: what iare the lengterm consequences of OBPL among adults? These questions are being adressed to with fhe ICF structure:- body…
The aim of the trial is to obtain data on the optimal dose, feasibility and pharmacokinetics of bumetanide when given as an add-on treatment for seizures in full term babies with hypoxic ischemic encephalopathy (HIE). Bumetanide will be given in a…
Probleemstelling: Er is geen duidelijkheid of rTMS, toegepast binnen het reguliere revalidatieprogramma na een beroerte, leidt tot een extra verbetering in motorische herstel volgens de klinimetrie zoals gehanteerd binnen de in Nederland gebruikte…
The primary objective of this explorative study is to evaluate the training effect on the upper extremity function of the (most) affected arm in unilateral activity, in children with unilateral and bilateral spastic Cerebral Palsy using the WiiTM…
Optimizing orthotic management in children with cerebral palsy to improve mobility and participation
The primary objective of this study is to evaluate AFO efficacy in children with spastic CP using outcome measures related to ICF the components of *body functions and structures* and *activities and participation*. The secondary aim is to identify…
The main objective of the study is to address the relative efficacy of botulinum toxin and 2-duct ligation in children with cerebral palsy, who suffer from severe drooling despite maximal conservative treatment.
To study if, how, and to what extent, cortical reorganization occurs in children with unilateral Cerebral Palsy after mCIMT.
to describe neurophysiological characteristics of *writhing* and *fidgety* GMs in typically developing young infants by means of multiple surface EMG recordings and kinematics.
The primary objective of this pilot study is to assess the prevalence of visual field defects in formerly eclamptic women. The secondary objective is to compare the vision-related quality of life between formerly eclamptic and normotensive parous…
Main group:EEG/ERP study (children and adolescents 4-17 years old)To quantify the effects of different intervention programs (mCIMT; BiT; combined mCIMT-BiT) on functional cortical processes involved in different aspects of motor behavior (i.e.…
The main objective of our research is to develop an FCE for use in one-handed individuals. The main objective of this part of the study is to gain descriptive data on muscle tension of the back, neck and shoulder, joint movements of the shoulder,…