41 results
Distinguishing frontal lobe epilepsy from ADHD in terms of working memory.
Primary Objective: - To gain insight on the underlying mechanisms of the variability of the response to ATN-DBS in patients with AED refractory epilepsySecondary Objective(s): - To gain insight in the neurophysiology of the anterior thalamic nucleus…
The objective of the study is to investigate if it is possible to predict the clinical outcome of a patient with SCN1A related epilepsy based on the findings of advanced genotyping. We aim to answer the following questions:1. Can clinical outcome in…
The primary objective of this trial are to assess the clinical usefulness (in terms of sensitivity and positive predictive value of 1. Combined heart rate and movement detection2. And the added value of video and audio detection in a population of…
A primary goal is to relate EEG based rsFC to changes in excitability of the brain. Since the excitability recorded with the MEPs reflect antiepileptic drug effects [1,2] it is assumed that these changes will be more pronounced after withdrawal of…
Primary objective of this study is to improve identification of epileptic HFOs in EEG and MEG, by comparing them to HFOs in corticography. Secondary objectives are to study the predictive value of non-invasively recorded HFOs for disease activity…
The primary objective of this investigation is to assess the performance of the ANSeR Software System by quantifying and comparing the diagnostic accuracy of investigation personnel using the ANSeR Software System with the diagnostic accuracy of…
To assess the provoking effect of partial sleep deprivation on paroxysmal neurological events in a EMU setting, in people with possible epileptic seizures.
Pilot study on additional value of 7T as compared to 3T MRI
In this research, a small group of children known to suffer from complex febrile seizures (FS) will be studied. An increase in expression of FS1 will be investigated in blood in comparison with an control group. This will be done by isolating FS1…
The primary objective of this study is to develop reliable signal analyzing methods for the monitoring of brain function in adult patients at risk for deterioration of brain function, (non)convulsive seizures or cerebral ischemia. The methods will…
Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch…
The overall main objective is to develop an optimal combination of sensors and techniques to detect major nocturnal seizures with high sensitivity and specificity in an extramural setting. The study we present here (which is phase 2 out of 3 of the…
The aim of this study is to investigate the interobserver variation in assessment of acute posthypoxische myoclonus in patients after cardiopulmonary resuscitation.
The study aims to answer the following questions: 1) What is the effect of Retigabine on cortical excitability measured by TMS ? (primary). 2) To what extent are changes in excitabilty meausred with TMS related to seizure control ? (secondary).
To investigate whether it is possible to induce epileptiform activity with TMS. We expect to see abnormal discharges on TMS-EEG and we expect that these findings are of diagnostic value and will help to localize the epilepsy.
The primary goal of this study is to develop a protocol for future studies in patients after a first seizure. We investigate 3 methodological aspects. - What is the effect on the auditory evoked potential of different types of noise masking?- What…
The primary objective of this study is to evaluate if there exists a circadian variability of the MEP and EEG response to single pulse TMS in healthy subjects. Secondary objectives are to:- investigate the accuracy of coil placement and the overall…
Is continuous EEG registration with a 9 and 21 channel EEG with SL detection an approved method for the detection of seizures in term neonates with perinatal hypoxia-ischemia? What are the sensitivity and the false positive rate of these methods in…
We want to address the following questions:How reliable is EEG-fMRI for epileptic source localization in difficult cases?Is EEG-fMRI able to replace intracranial EEG studies?