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A randomized, double-blind, placebo-controlled study to investigate the efficacy and safety of cannabidiol (GWP42003-P) in children and young adults with Dravet syndrome.

To assess the efficacy of GWP42003-P as an adjunctive antiepileptic treatment compared with placebo, with respect to the percentage change from baseline during the treatment period of the study in convulsive seizure frequency. The dose response…

Stimulation of the anterior thalamic nucleus in refractory epilepsy:
Neurophysiological aspects and effects on cognition

Primary Objective: - To gain insight on the underlying mechanisms of the variability of the response to ATN-DBS in patients with AED refractory epilepsySecondary Objective(s): - To gain insight in the neurophysiology of the anterior thalamic nucleus…

The 'Livassured' Combined Sensor system to detect Epileptic Noctural SEizures (LICSENSE)

The primary objective of this trial are to assess the clinical usefulness (in terms of sensitivity and positive predictive value of 1. Combined heart rate and movement detection2. And the added value of video and audio detection in a population of…

Pharmacokinetic and pharmacodynamic modelling of routinely used off label drugs in premature neonates

Recently, population PK/PD modeling and simulation studies have enabled the development of evidence-based individualized dosing schemes for children with a limited number of subjects, thus improving drug safety and efficacy. The application of PK/PD…

Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy - Tuberous Sclerosis Complex.

The primary objective of the clinical part of EPISTOP project is to identify the clinical and molecular biomarkers of epileptogenesis in a prospective clinical study of patients with TSC. Secondary objective of the clinical part of EPISTOP is to…

Characterisation of neurotransmitter network dysfunction in MRI-negative localisation-related epilepsy

To compare the neurotransmitter networks of patients with localisation-related epilepsy patients to those of healthy subjects; To explore the relationship between neurotransmitter, functional and structural network properties, and relate these to…

Paired pulse TMS-EEG in epilepsy: improving the diagnostics process

The primary objective of this study is to evaluate differences in motor evoked potential (MEP) and TMS evoked potential (TEP) to paired pulse TMS between epilepsy patients and healthy controls. Secondary objectives are 1) To evaluate differences in…

Intracranial registration in patients with refractory epilepsy, an integrative analysis of brain signals in response to sensory stimuli

To identify neuronal activation patterns in response to cognitive stimuli

Novel methods for function mapping and BCI in children

In the current proposal, two primary objectives will be addressed. The first is to establish the spatial correspondence between fMRI, ECoG/stereo-EEG and ECS for different brain functions in children. The second is to investigate the feasibility of…

Paired pulse TMS-EEG in epilepsy: improving the evaluation of therapeutic efficacy

The primary objective of this study is to evaluate differences in motor evoked potential (MEP) and TMS evoked potential (TEP) to paired pulse TMS between epilepsy patients with a successful response to AEDs and those who do not (refractory patients…