126 results
The primary objective of the study is to investigate changes in white matter structural integrity in patients with relapsing remitting multiple sclerosis (MS) after treatment with dimethyl fumarate and its relation to physical and cognitive…
To evaluate the effect of digital self-monitoring-based management of relapsing and remitting multiple sclerosis on self-efficacy, clinical outcome measures and cost-effectiveness
To evaluate safety, tolerability pharmacokinetic profile; to explore pharmacodynamics; to evaluate major effects of Guanabenz on quantitative MRI and clinical parameters in pediatric patients with VWM; explore biomarkers in blood and cerebrospinal…
The PROUD-kids 2.0 study aims to find parameters to identify and distinguish between the different subtypes of ADS. Also finding predictive factors for disease course and disease severity. Genetic and environmental factors will be investigated to…
The primary objective of this study is to assess whether the cause of neurological deterioration in patients with RRMS/CIS is a real relapse, a pseudo-relapse or mimic and compare these groups on baseline characteristics. Secondary objectives: * To…
To identify prognostic factors for disease course and severity, as soluble and cellular biomarkers, immunological, genetic, radiological and demographics factors.
We will prospectively collect spinal cord MRI data (in addition to routine brain MRI), and blood-based biomarkers (plus cerebral spinal fluid markers, if available), in recently diagnosed MS patients, to address the following research questions: 1…
The main objective of this study is to determine how well the Multiple Screener© can differentiate between patients with no cognitive deficits, mild cognitive deficits and cognitive impairment. Additionally, we aim to confirm the observed accuracy…
This first-in-human study is planned to include both a dose ranging phase and a confirmatory phase, with the intention that all data collected throughout the study may support registration. The dose ranging phase will be conducted in cohorts of 3-4…
Primary Objective:What is the effect of a four-weeks combined TENS and exercise program, in comparison with no training, an exercise program or TENS only program, on the walking capability, perceived walking disability, and sense of fatigue of pwMS.…
In this pilot study, we aim to investigate if increasing field strength beyond 7T will result in additional advantages in characterization of MS lesions in vivo and to identify its limitations and technical challenges. More specifically, firstly, if…
With this study we aim to prove that personalized B cell tailored ocrelizumab treatment is non-inferior in the suppression of MS disease activity (clinically and radiologically) compared to the standard (fixed 24 week interval) treatment.
To perform long-term pre-specified follow-up of patients undergoing aHSCT for refractory RRMS.
(1) To compare the efficacy of two innovative preventative interventions with a control intervention in improving quality of life, cognition, work participation and productivity, brain plasticity and resilience, (2) to gain insight into the…
This study has been transitioned to CTIS with ID 2024-513105-31-00 check the CTIS register for the current data. Primary Objective: Our objective is to validate the safety, measured by radiological disease activity, of personalized extended interval…
This study has been transitioned to CTIS with ID 2024-512345-16-00 check the CTIS register for the current data. The purpose of this BIVV020 Phase 2 study is to determine the preliminary efficacy, safety, and tolerability of BIVV020 in three CIDP…
The main objective of this project is to build a comprehensive model for a better predictio n of progression in MS, as a first step to move towards personalized prediction. Secondary objectives aim to study specific aspects of underlying mechanisms…
To describe the efficacy and safety of a maintenance versus induction anti-CD20 treatment strategy in pwMS.
The main objective of this project is to validate a standardized volume measurement system (using eight in-house 3D printed phantoms) to allow for reliable atrophy measurements in MS, by quantifying between-scanner and within-scanner reproducibility…
Primary Objective: • To compare the proportion of MS patients with OCBs between patients with and patients without recurrent disease 12 months after cessation of DMTs. Secondary Objectives: • To explore differences in CSF/ blood IgG indices between…