41 results
PROUD is a multicentre prospective study, using clinical factors in combination with additional tests with the aim to clarify more about the aetiology and pathogenesis of MS.
To identify (clinical) features of MMN patients that predict a poor clinical disease course. Moge agressive IVIg regimen can be established is this subgroup to maintain functional status of the patient. To find domains in quality of life in MMN…
To determine whether damage in the cortical and/or subcortical GM in patients with early RRMS increases in regions connected to more damaged WM tracts, i.e. WM tracts with larger lesion volume, WM tracts with more severe damage inside lesions, and/…
The main objective of this study is to investigate if the occurrence of cognitive impairment and functional reorganization *defined as increased functional activation in cognitively preserved patients- in MS can be explained by changes in GABA and…
How does motor fatigue influence the cognitive functioning of patients with MS and how does this interaction compare to that in healthy controls?
(1) to establish the neuropsychiatric and personality status (symptoms and impairments) (2) to assess the possible determinants of these symptoms and impairments and (3) to examine the impact of these symptoms and impairments on daily life…
The primary objective of this study is to determine the prevalence and degree of impaired cerebral venous drainage in MS patients in comparison to healthy subjects.Secondly, we want to determine a possible relationship between the degree of impaired…
Is subjective fatigue in patients with MS related to a combination of force reduction during a fatiguing task and depression score?
Primairy objective:* To assess whether a poor vitamin D status in RRMS patients is negatively associated with cognitive performance in neuropsychological tests (information processing speed and working memory) and with measures of cognitive (dys)…
The objectives of this initiative are:1. To establish the disease oriented biobank; processing and storage of blood and CSF specimens and health information of MS patients (which may include health records, family history, lifestyle and genetic…
How large is the force decrease in patients with secondary progressive MS, what is causing this decrease. In addition, is the cognitive performance of secondary progressive MS patients influenced by a fatiguing motor task?
Primary Objective: The primary aim of this proposal is to identify miRNA profiles that can be used as novel MS biomarkers and to design a test, based on these profiles, that can be used in clinical practice.Key objectives are:(1) deep-sequencing of…
Isolation of skin fibroblasts from MS patients for reprogramming into induced pluripotent stem cells
In this study we aim to address the hypothesis that oligodendrocytes and oligodendrocyte precursor cells from MS patients exhibit epigenetically determined differences in protein expression profiles and functional behavior in comparison to those…
Primary Objective• To demonstrate feasibility of measuring deuterium incorporation into galactosylceramides within the quantitation limits of the assay, in human CSF after chronic dosing of D2O.• To develop a mathematical model to allow estimation…
To assess the usefulness (sensitivity) of magnetic resonance imaging (MRI) in detecting TCP-induced changes in neurobiological markers induced by engine oil fumes.
The primary objective of this study is to assess whether the CD4+ T cell compartment displays a less pro-inflammatory profile in patients which are supplemented for the SOLAR study with high doses of vitamin D3 when compared to patients which are…
The aim of the proposed study is to get more insight into the role of the hippocampus and thalamus in cognitive impairment in MS patients. To achieve our goal, we propose to study the (abnormal) structure and function of the two structures with…
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
The objective of this study is the visualisation of diffuse and focal lesion in the brain in Multiple Sclerosis on higher main magnetic fields. Images from 1.5 Tesla MR scanners will be compared with images acquired at 3 Tesla and images made on 3…
Aim: 1) To continue studying (the determinants of) the decline in functioning in the domains neurological deficits, physical functioning, mental health, social functioning and general health in the first 9 years after the diagnosis, and 2) to study…