Search for a trial

Chronic pain experience in adults with Down syndrome, with and without dementia, and the relationship with cognitive functioning.

The first aim of the present study is to examine whether the pain experience in adults with Down syndrome (without dementia) differs from the pain experience in adults without intellectual disability, after correction for mentale age, comorbidity…

Neurofeedback as a remediation for late neurocognitive sequelae in survivors of childhood brain tumours: a pilot study

The aim is to study if Neurofeedback can be an applicable intervention.for survivors of childhood brain tumours. The QEEG wil be investigated whether under or overactive brainareas exist which can be trained. This study will also investigate whether…

Cognitive shifting as a predictor of agression in people with intellectual disabilities and autism spectrum disorders.

This hypothesis will be challenged in five objectives:1. To check the factorial validity of two cognitive styles - weak central coherence; poor cognitive shifting - in patients with MR and ASS.2. To assess the specificity of the association between…

Open-label, non-randomized, multi-centre positron emission tomography (PET) imaging study to evaluate a single dose of 250 MBq BAY858102 ([F-18]DPA-714) for its diagnostic potential in discriminating patients with probable Alzheimer's disease from healthy volunteers and to evaluate the radiation dosimetry of a single dose of 150 MBq BAY858102 ([F-18]DPA-714) in healthy volunteers

Based on the scientific background and knowledge as detailed above this clinical proof-of-mechanism study is performed in order to determine if PET imaging with [18F]DPA-714 has the diagnostic potential to discriminate probable AD patients from…

Correlation of White Matter Fractional Anisotropy Measurements at 3T MRI with Neurocognitive Function in Childhood Cancer Survivors: a Pilot Study

AimThe aim of this study is to determine if WMFA measured by DTI at 3T MRI in cancer survivors is a suitable biomarker in children between 8 -16 years of age for treatment induced neurotoxicity and related neurocognitive deficits.

Imitation, sensitivity for cues, complementary and joint action of children and adolescents with autism spectrum disorder.

The aim of this study is to investigate the hypothesis that persons with ASS may be less capable of 'reading' the behavior of others and because of that they may be less capable of complying to others, leading to social and/or behavioral…

Brain imaging of language function in autistic spectrum disorders

The primary objective of this study is to identify the neural correlates of language functions and, in particular, abnormal pragmatic communication in autistic spectrum disorders.

Genetic causes of 'TOS' (developmental language disorder)

With this study, we aim to shed light on the possible use of diagnostic next generation sequencing in DLD, by determining the diagnostic yield of WGS in this important class of neurodevelopmental disorder. In addition to determining this diagnostic…

Moses II - Measuring Elecsys β-Amyloid (1-42) II and Phospho-Tau (181P) in CSF Samples supporting Phase 2 Clinical Trial of 247AD201 (BIIB080)

The primary objective of the diagnostic study is to analyze the CSF measurements of β-Amyloid (1-42) (Aβ 42) and Phospho-Tau (181P) (pTau) using Elecsys β-Amyloid (1-42) CSF II and Elecsys Phospho-Tau (181P) CSF in the screening samples of the phase…

Financial decision-making in patients with neurodegenerative disorders - a pilot study.

The primary objectives are to investigate multiple aspects of FDM in patients with AD, MCI and PD compared to healthy controls and to investigate whether FDM problems in these patients can be related to specific neurocognitive dysfunctions. The…

Detailed Speech & Language Phenotyping in SATB2-Associated syndrome

With this study we aim to define a detailed oral motor, speech and language profile for patients with SAS.