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A Biomarker Study to Measure CSF Proteins Upon Application of an Indwelling Lumbar Catheter for 36 Hours in Subjects with Mild Cognitive Impairment or Alzheimer*s Disease

Primary ObjectiveTo investigate changes of CSF proteins over time using continuous CSF sampling for 36 hours, including but not limited to A*1/x-42, A* 1/x-40, A* 1/x-38 and A* 1/x-37 in subjects with MCI or AD. Secondary Objectives1. To investigate…

Assessment of Safety, Tolerability, and Pharmacodynamic Effects of LY2886721 in Patients with Mild Cognitive Impairment Due to Alzheimer*s Disease or Mild Alzheimer's Disease

Assessment of Safety, Tolerability, and Pharmacodynamic Effects of LY2886721 in Patients withMild Cognitive Impairment Due to Alzheimer*s Disease or Mild Alzheimer's Disease

Treatment of central pain syndromes by caloric vestibular stimulation

Objective of the study: With this pilot study we attempt to explore the possibility to treat patients suffering from intractable neuropathic pain with CVS

Cognitive impairment following cardiac arrest and Target Temperature Management
(A sub-study of the TTM Trial)

Understanding the cognitive disorders in patients who have woken up after a resuscitation and who were treated with a controlled temperature during the ICU treatment

Chronic pain experience in adults with Down syndrome, with and without dementia, and the relationship with cognitive functioning.

The first aim of the present study is to examine whether the pain experience in adults with Down syndrome (without dementia) differs from the pain experience in adults without intellectual disability, after correction for mentale age, comorbidity…

A Double-Blind, Placebo-Controlled, Randomized, Parallel Group, 12-Month Safety and Efficacy Trial of Leuco-methylthioninium bis(hydromethanesulfonate) in Subjects with Behavioral Variant Frontotemporal Dementia (bvFTD)

Primary:To demonstrate the efficacy of LMTM as assessed by the change from Baseline on:* Addenbrooke*s Cognitive Examination Revised (ACE-R)* Symptomatic effect as reflected by the Functional Activities Questionnaire (FAQ)* Disease-modifying effect…