32 results
The primary objective of the proposed study is to investigate whether bumetanide therapy indeed reduces autistic symptomatology. Important secondary goals of this project are to determine whether bumetanide will improve specific behavioral,…
The aim of the study is to understand the nutritional status of people with complex multiple disabilitiest through measurement of body composition and nutritients.The primary objective of the study is:What percentage of people with complex multiple…
1) to gain insight in the pathophysiological mechanisms leading to intellectual disability and 2) to create a model system which allows screening of therpeutic interventions for efficacy.
The first aim of the present study is to examine whether the pain experience in adults with Down syndrome (without dementia) differs from the pain experience in adults without intellectual disability, after correction for mentale age, comorbidity…
The aim is to study if Neurofeedback can be an applicable intervention.for survivors of childhood brain tumours. The QEEG wil be investigated whether under or overactive brainareas exist which can be trained. This study will also investigate whether…
This hypothesis will be challenged in five objectives:1. To check the factorial validity of two cognitive styles - weak central coherence; poor cognitive shifting - in patients with MR and ASS.2. To assess the specificity of the association between…
The main objective of the study is to reach an etiological diagnosis in as many cases of a selected group of MR patients. The aim is to do so in at least 15-20% of hitherto unexplained MR.Also an objective is the establishment of a genetic-…
Based on the scientific background and knowledge as detailed above this clinical proof-of-mechanism study is performed in order to determine if PET imaging with [18F]DPA-714 has the diagnostic potential to discriminate probable AD patients from…
To investigate the relation between the amyloid metabolism (as measured by plasma Abeta1-40 en 1-42) and the incidence of dementia in DS patients and the investigate whether there is interaction with vascular or genetic factors with respect to this…
AimThe aim of this study is to determine if WMFA measured by DTI at 3T MRI in cancer survivors is a suitable biomarker in children between 8 -16 years of age for treatment induced neurotoxicity and related neurocognitive deficits.
Our project focuses on the function of transporters and deiodinases in the (dys)regulation of intracellular T3 levels in patients with psychomotor retardation and abnormal serum thyroid hormone levels. The main objectives of our study are:1. To…
1. Define the clinical spectrum in female carriers of creatine transporter defect. 2. Correlate the clinical phenotype with X-inactivation studies.
The primary goal of this research project is the identification of genes involved in causing mental retardation. These genes will be part of genetic networks that play a role in normal brain development and function. With up-to-date bioinformatic…
The aim of this study is to investigate the hypothesis that persons with ASS may be less capable of 'reading' the behavior of others and because of that they may be less capable of complying to others, leading to social and/or behavioral…
The primary objective of this study is to identify the neural correlates of language functions and, in particular, abnormal pragmatic communication in autistic spectrum disorders.
The purpose of the present study is to try to classify autistic children into distinct subgroups, by clinical morphological examination. We mainly want to answer the following questions: 1) Is there an increased prevalence of minor anomalies in…
The primary objective of the study is to test the effectiveness of bumetanide across the whole spectrum of sensory processing disorders within ASD, ADHD and/or epilepsy. We also want to determine which subgroups (high/low IQ, comorbidities or not)…
Our research aims to establish informative tools in the laboratory for studying the molecular and cellular pathways that are altered in SETBP1 disorder.
Primary objective: To evaluate whether intellectual disability and facial dysmorphology are associated with an increased clinical diagnostic yield of genetic testing among patients with a psychiatric illness.Secondary objective: To investigate the…