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Safeguarding the brain of our smallest children ;* an investigator-initiated randomised, blinded, multinational, phase II
feasibility clinical trial on near-infrared spectroscopy monitoring
combined with defined treatment guidelines versus
standard monitoring and treatment as usual in premature infants

The primary objective of the SafeBoosC trial is to examine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants (gestational age < 28 wks) during the first 72 hours of life through the application of cerebral…

Prevention of renal and bladder damage in children with spina bifida by means of early injections with Botulinum-Toxin-A (Botox): a pilot study.

- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…

Reconstruction of the optic radiation using enhanced DTI compared to HARDI

In this study the potential of using the enhanced procedures for analyzing diffusion weighted data which were acquired according to clinical procedures is further investigated. The result is compared to the reconstruction of the OR based on high…

A prospective randomised open label study to determine the best dose escalation scheme of dipyridamol added to acetylsalicylic acid, based on the side-effect headache, in patients starting secondary preventive therapy for stroke

To determine the best dose escalation scheme of dipyridamole added to acetylsalicylic acid, based on the side-effect headache, in patients starting secondary preventive therapy for stroke

AMYPAD Prognostic and Natural History Study (PNHS), an open label, prospective, multicentre, cohort study in individuals without dementia to evaluate the additional value of quantitative amyloid imaging in determining Alzheimer*s Disease (AD) dementia risk

The aim of this study is to evaluate the additional value of quantitative amyloid imaging analysis for modelling and assessing Alzheimer*s Disease (AD) dementia risk in individuals without dementia, compared to a range of existing cognitive, imaging…

European Prevention of Alzheimer's Dementia - Longitudinal Cohort Study (EPAD-LCS)

1. To provide a well-phenotyped population (readiness population) for the EPAD PoC trial to minimize trial screening failures 2. To provide a well-phenotyped probability-spectrum population for developing and continuously improving disease models…