35 results
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
The main objective of the study is to investigate MEG-based hippocampal and whole brain neuronal hyperactivity in preclinical DIAD mutation carriers and to find proof-of-concept for the translatability of findings from preclinical AD mouse models to…
To determine the intra-individual variation of various potential blood based biomarkers on consecutive days or weeks.
To validate analytical parameters of blood-based biomarker methods and assess the influence of pre-analytical blood handling on levels of those biomarkers.
In this project, we will combine cohorts from several countries into a comprehensive retrospective discovery cohort to examine theabove-mentioned markers focusing on sporadic cases and PPD, in addition to a large number ofpathologically confirmed…
To investigate the neurological and neuropsychological sequelae of COVID-19 infection for which ICU or non-ICU hospital admission was necessary in the spring of 2020 and for which ICU admission was necessary in the fall of 2020, and its consequences…
To assess protein-specific synthesis rates neocortex, hippocampus, temporalis muscle, and vastus lateralis muscle using the D2O dosing method.
1. To examine whether there is an increase in (nigro)striatal dopaminergic functioning in individuals of West-African descent relative to those of Dutch descent (assessed in older participants with DAT SPECT and with NM-MRI in the entire sample). (…
This study aims to relate factors of hypercoagulability, inflammation or general illness itself (all during ICU admission) to microstructural and microvascular abnormalities on follow-up brain advanced 3T and 7T MRI in COVID-19 ICU survivors. By…
To overcome the heterogeneity dilemma that hampers drug development, we propose a translational within-subject approach that integrates clinical, pathological, and molecular/cellular data of induced pluripotent stem cells (iPSC) derived neurons and…
The aim of this research is to study which biological processes precede and can predict loss of brain connectivity in a longitudinal study in 55 individuals with predementia AD, for whom a potential intervention may have maximal effect.This research…
Our primary objective is to investigate the relation between atypical IMP and SINDA scores in infancy and symptoms of DCD at 4-5 years of age measured with the Movement Assessment Battery for Children - 2nd edition. The relation will also be…
The first aim is to determine an objective acoustic measure to define SMS by comparing acoustic features of probe words to a perceptual score of speech motor movement characteristics and stuttering frequency judged by the expert (i.e., the current…
Primary Objective: The aim of the proposed project is to assess (a) neurocognitive performance and (b) structure and function of brain networks in retired female football players compared to a matched control group of retired female elite athletes…
Assessment of emotion recognition in patients who suffered an ischemic cerebellar stroke in the past 3 years.