209 results
To obtain normal values for neuromuscular ultrasound parameters in adults.
In this pilot study we aim to investigate the additional value of sEMG signals of respiratory muscles during ICU admission in adults.
To investigate whether the CVS patients show the muscle membrane disturbances, as the FMS patients do. That is, are there muscle conduction velocities disturbances in the CVS patients?
To optimize ventilator support in critically ill patients admitted to the intensive care unit by monitoring electromyography of the respiratory muscles.
Shoulder load and daily activities compared between power assisted and manual wheelchair propulsion.
The primary objective is to compare forces and moments acting on the shoulder of manual wheelchair users during power assisted wheelchair propulsion and manual wheelchair propulsion and the perceived upper extremity load. The secondary objectives…
Primary:To assess the safety and tolerability of Firdapse after single and multiple doses Secondary:Part 1 only: To determine the dose-related PK profile of single, escalating doses of Firdapse;Part 2 only: To assess the steady-state plasma PK and…
The main objective of this prospective cohort study of patients with proximal SMA in the Netherlands is to investigate the function of the neuromuscular junction by means of repetitive nerve stimulation (RNS).
To develop a screening test to predict ICU-AW at an early stage in patients admitted to the ICU. Also by prospectively following the patient group in time, this study aims to describe the natural history and functional limitations in patients…
PrimaryTo investigate the inter-rater and intra-rater variability of a novel neurophysiological measurement (Motor Unit Number Index, MUNIX) for estimation of functioning motor units, in healthy controls and ALS patientsSecondaryTo evaluate the…
1. To investigate the possible relationship between amount of dystrophin expression and clinical severity of BMD2. To investigate the relationship between specific BMD-gene mutations and clinical severity of BMD3. To investigate possible other…
The primary objective is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure. Furthermore, the hypothesis whether diaphragm efficiency (Effdi = electrical activity of…
The purpose of this study is: 1) to develop a method to quantify muscular fat content in brachial plexus injury patients;2) to investigate whether muscular fat content is more in the affected arm compared to the contralateral arm in BPI patients;3)…
In this study we want to investigate if relaxation time (RT) measured by handgrip myometry and muscle- elastography is a reliable outcome measurement for the quantification of myotonia in NDM patients. Mean RT values en standard deviations of NDM…
Objective: to identify potential predisposing and modifying factors of MG in order to improve understanding of the mechanisms of disease, diagnostics and treatment.
Does mitochondrial dysfunction play an important role in the pathofysiology of patients with Complex Regional Pain Syndrome Type I ?
2.1 Primary Objectives: 1) To test the feasibility of the six minute assisted leg and arm cycling test in patients aged 6-18 years with Duchenne muscular dystrophy (DMD), Beckers muscular dystrophy (BMD), Limb Girdle muscular dystrophy (LGMD),…
Main objectiveTo describe the experienced pain sensations of temperature and to describe the different temperature sensitivity thresholds using Quantitative Sensory Test (QST) in the different patient groups.secondairy objectiveAs a measure of the…
Within this complete European consortium animal models as well as patient material are utilized, in order to uncover the pathogenic pathways in OPMD that are at the centre of the disease, eventually in order to design rational evidence based…
The objective of this study is to learn from young people with a chronic illness (diabetes or progressive muscular disease) who have found a balance between taking good care of their illness and having a good life. This study examines how these…
To evaluate the long term changes in quadriceps muscle function in patients with PPS in comparison with control subjects. To correlate changes in muscle strength, functioning and symptoms with changes in motor unit size. To evaluate long-term…