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A Phase I, drug-drug interaction study between oral doses of GLPG1205 and an OCT2 probe substrate (metformin) or a BCRP probe substrate (rosuvastatin) in healthy male subjects

PrimaryTo assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of an OCT2 probe substrate, metformin, in healthy male subjects.To assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of a BCRP probe substrate,…

Efficacy of vitamin D supplementation in preventing peripheral neuropathy in multiple myeloma patients.

The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.

Double blind, randomized, 2-way cross-over, placebo controlled study to evaluate the therapeutic and preventive effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model in healthy male subjects

PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…

Boneloss following immobilization in diabetes mellitus, an inventory using an ultrasound method (BINDEX).

The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…

A single-center, open-label, single oral dose study to investigate the absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetics of EMA401 after a single dose of [14C]EMA401 in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent EMA401 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). EMA401 will be labeled with 14-Carbon (14C) and is…

Venlafaxine for prevention of oxaliplatin-induced peripheral neuropathy - A randomised clinical trial

Given the significant number of patients with OIPN and the possible prophylactic properties of venlafaxine, this study is designed. This study will consist of a randomised placebo-controlled clinical trial to study the prophylactic effect of…

Follow-up of carpal tunnel syndrome

We aim to investigate the amount of patients who have lasting benefit from such surgery, and which proportion eventually get recurrent symptoms. We are going to investigate the cohort which has previously been studied by our group (protocol Dr.…

The Dutch Injection versus Surgery TRIal in Carpal Tunnel Syndrome patients

The objective of this study is to assess the efficacy and cost-effectiveness of a treatment strategy starting with surgical intervention compared to a starting treatment with steroid injection.

Old Title: International, multi-center, open label 9-month FOLLOW-UP extension study assessing the long term safety and tolerability of PXT3003 in patients with Charcot-Marie-Tooth Disease type 1A.;New title : International, multi-center, open label FOLLOW-UP extension study assessing the long term safety and tolerability of PXT3003 in patients with Charcot-Marie-Tooth Disease type 1A.

The primary objectives:Period 1:The primary objective is to assess the long-term (up to 2 years) safety and tolerability of two doses of PXT3003.Period 2:For patients continuing after V9, the main objective will be to offer patients the opportunity…

Pilot study on 3D-Ultrasound of Peripheral Nerves

In this pilot study we want to investigate if 3D ultrasound can adequately visualize long nerve tracts and if 3D reconstructions of nerves and volumetric measurements can be made with this technique. If this is the case, this could not only decrease…

VX16-150-102 A Phase 2, Randomized, Double-blind, Placebo-controlled, 6-Week, Parallel-design Study of the Efficacy and Safety of VX-150 in Treating Subjects With Pain Caused by Small Fiber Neuropathy

Primary Objective:To evaluate the efficacy of VX-150 for the treatment of pain caused by small fiber neuropathy.Secondary Objectives:* To evaluate the safety and tolerability of VX-150* To evaluate the pharmacokinetics (PK) of VRT-1207355 and the…

Spinal cord stimulation for treating diabetic neuropathic pain; a validation study

To validate the results from two RCTs that SCS is indeed capable of treating otherwise refractory diabetic neuropathic pain, and to evaluate the effects of burst stimulation settings in this patient group.

Innate immunity in the Guillain-Barré syndrome

This protocol is aimed at investigating three research questions related to innate immunity in GBS:1. Do patients with viral GBS have a different innate response to microbial triggers compared to healthy controls?2. Do patients with recurrent GBS…

Prevalence of neuropathic pain in one year survivors after intensive care admission

Our primary objective is to determine the prevalence of neuropathic pain within one-year ICU survivors. A secondary objective is to compare patient and disease characteristics between patients reporting neuropathic versus other pain, in order to…

A phase I, randomized, placebo-controlled, double blind, first time in human, escalating single-dose study to evaluate the safety, tolerability pharmacokinetics and pharmacodynamics of Neu-P12 in healthy male volunteers

Primary objectiveTo assess safety and tolerability of Neu-P12 in four different single doses of the drug. Secondary objectiveTo compare the pharmacokinetics, pharmacodynamics, safety, and tolerability of different single doses of Neu-P12.