223 results
This randomized phase II open label study examines the effect of controlled cooling versus no cooling on the incidence and severity of oxaliplatin-induced peripheral neuropathy (OIPN) in patients treated with oxaliplatin.
Use Magneto-encephalography (MEG) to image the cortical and thalamic effects that underlie the analgesic effects of SCS for chronic pain patients. To analyse the differences in cortical and thalamic activity between SCS ON and SCS OFF.
The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to CIAP. The second objective is to determine the predictive value of a DOBRET to identify sustained responders.
Primary objective:To evaluate the efficacy of ION-682884, based on the change from Baseline in serum Transthyretin (TTR) concentration, modified Neuropathy Impairment Score +7 (mNIS+7), and Norfolk Quality of Life Questionnaire-Diabetic Neuropathy (…
The primary objective is to investigate the intra- and inter-session reliability and construct validity of the FootWork Pro platform and in-shoe system in neuropathic diabetic patients. The secondary objective is to investigate the feasibility of…
Objective: The primary objective is to improve defining clinical phenotypes of PHN patients using the following diagnostics; questionnaires, QST, blood and cerebrospinal fluid (CSF) assessment and skin nerve fiber density measurements. The secondary…
The objective of this study is to assess the efficacy and cost-effectiveness of a treatment strategy starting with surgical intervention compared to a starting treatment with steroid injection.
We aim to investigate if the E-PSS is able to discriminate patients with polyneuropathy from patients without polyneuropathy in patients with diabetes and/or chronic kidney failure and determine an optimal cut-off value. Primary Objective: Is the…
Determining the feasibility of EVNS performed at home by the patient and/or caregiver, after instruction from the podiatrist.
The primary objective is to gain information regarding the natural course of SFN and the change over time of the diagnostics using clinimetrically sound outcome measures representing various levels of outcome assessment. The secondary objective is…
The primary research question of the trial is to assess whether foot drop, caused by peroneal nerve entrapment in adult patients* recovers better within 9 months after decompressive surgery compared to prolonged standard conservative treatment. *…
The main objective is that a cognitive behavioral intervention for patients with SFN will have a positive effect on disability and quality of life.
Primary Objective: to show a reduction in eGFR decline in patients treated with LCP tacrolimus compared to IR tacrolimus. Secondary objectives will include investigating the potential decline in other known side effects of calcineurin inhibitors i.e…
In this study, we will determine the IENFD after at least one year since the first skin biopsy was taken, in patients with the diagnosis of SFN based on the clinical picture and abnormal TTT, but with a normal IENFD at presentation. A biopsy will be…
The primary objectives:Period 1:The primary objective is to assess the long-term (up to 2 years) safety and tolerability of two doses of PXT3003.Period 2:For patients continuing after V9, the main objective will be to offer patients the opportunity…
The primary aim is to investigate the effect of neuromodulation (via UCon) on the symptoms of patients with PGAD. The hypothesis we want to test is whether neuromodulation of the DGN reduces the severity of symptoms of PGAD.
Our primary objective is to determine if there is a reduced IENFD in patients with ACNES. We hypothesize there will be a reduced IENFD of the affected skin (side of the pain) in comparison to the non-affected side. Our secondary objectives are to…
The primary objective is to determine whether in patients with CIPN pain, treatment with Qutenza has the same effect as treatment with duloxetine
Our primary objective is to determine if there are (gain-of-function) mutations of Nav1.7 and Nav1.8 in patients with ACNES.Our secondary objective is to see if there is a difference between patients with and without mutations, and:- Known…