132 results
The objective of this study is to validate the VBMEG algorithm by comparing hd-EEG with fMRI activity. If validated, it will be validated that the accuracy of the VBMEG algorithm is improved when fMRI is incorporated to the source reconstruction,…
The objective of this study is to examine the effect of riluzole on the glutamate/GABA balance in the brain in patients with 22q11.2DS. The secondary objective is to examine the effects of riluzole on psychotic symptoms and cognitive functioning. In…
This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…
The primary objective of this pilot study is to investigate the feasibility of GMT with a new game that incorporates strategy training inimproving executive functions in a pilot sample of brain-injured patients. This study investigates the usability…
Primairy objective:Explore the prevalence of the ABI-effect, by mapping the participation level. Secundary objective:Substatiate the occurence of the ABI-effect, by mapping cognitive functions of patients and compare these to healthy controls.…
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…
The objective is to identify which eye movement features are sensitive biomarkers for FTD. To answer this question, we will assess which eye movement features dissociate best between healthy controls, patients with FTD (familial and non-familial),…
This study has been transitioned to CTIS with ID 2024-517634-17-01 check the CTIS register for the current data. The main objectives are to 1) investigate the relation between (longitudinal) tau and amyloid accumulation in cognitively normal…
To explore the efficacy of central thalamic DBS in restoring consciousness in MCS patients. Hypothesis: Central thalamic DBS improves the level of consciousness in MCS patients.
We address two primary objectives: 1.) To determine whether (awake) surgery on patients with a brain tumor or epilepsy allows for HD-ECoG data collection of adequate quality to address research questions on brain function. In other words, we want to…
This proof-of-principle evaluation aims to investigate whether a home-based balance training using an exergame (HEROES), following a single session of perturbation-based training improves reactive step quality in people with chronic stroke.
The primary objective is the evaluation of the potential positive effect of a compensatory memory strategy game on effective coping with memory problems and reducing subjective memory failures in ABI patients with memory deficits in the chronic…
The BeyeOMARKER study*s primary aim is to (1) evaluate the real-world predictive value of blood- and eye-based biomarkers for detection of AD-related clinical progression and biological changes in eye clinics. Secondly, we aim (2) to assess the…
The current study aims to obtain a better understanding of glymphatic dysfunction in dementia of the Alzheimer*s type and its preclinical stages.The main objective of this study is to improve our understanding of the potential link between…
To examine the cross-cultural acceptability of four interventions in dementia care that typically aim to increase control over the end of life among people with dementia, and family and professional caregivers. Differences in acceptability between…
The precise pathophysiology for hypertension causing brain damage is still unclear, although microvascular dysfunction is thought to play an important role. Therefore, in this study the small cerebral vessels will be studied in more detail. The main…
This study has been transitioned to CTIS with ID 2024-518559-41-01 check the CTIS register for the current data. The main objectives are to identify markers for amyloid pathology in cognitively normal subjects, to identify risk factors for amyloid…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
(1) investigate alterations in executive functioning in extremely preterm-born adolescents in the Netherlands relative to term-born controls, (2) assess the neurobiological basis of individual variability in executive functioning following preterm…
We aim to assess the association between variability and irregularity in heart rate (as caused by permanent atrial fibrillation), and cognitive function. In addition, variability and irregularity of the peripheral blood pressure will be correlated…