74 results
The primary objective of this study is to assess whether motor learning using external attentional focus instructions results in superior single-task motor performance, movement automaticity, and dual-task performance in inpatient stroke patients…
To evaluate the effects of tDCS on information processing speed in comparison to sham tDCS in patients after stroke with ascertained reduced processing speed. A proof of principle study.
To investigate in an unselected memory clinic sample, the clinical value of 18F]FBB PET in terms of1. change in diagnosis;2. change in level of confidence of diagnosis;3. impact on patient healthcare management.
1) Is e-COGRAT usable within the ABI population?2) What are the patients* experiences with e-COGRAT?3) What are the therapists* experiences with e-COGRAT?4) What changes in the e-COGRAT are necessary?5) Does this pilot with e-COGRAT show a decline…
A. To gain more knowledge about the prevalence of TBI in male prisoners in the PPC and the relationship of TBI with violent crime and aggression. We expect that TBI is more common in violent offenders than in non-violent offenders. More specific, we…
To determine the relative bioavailability of pramipexole 4.5 mg tablets vs. 4.5 mg Sifrol in healthy subjects after up-titration.
To report on (the age-dependency of) the long-term effect(s) of chronic SSRI treatment during adolescence or adulthood on the outgrowth and function of the 5-HT system, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques and other,…
The primary objectives are defined according to a hierarchical design: i) to tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in DM2 and MetS; ii) to investigate which cerebral…
The current study will focus on the effects of an intensive programme of exposure of prism adaptation (i.e. daily exposure during two weeks) and compare these to sham adaptation.
The most important objective of this study is the validation of various examination procedure to assess fitness to drive in older persons with cognitive impairments. The assessment procedure comprises nosological dementia diagnoses (e.g. AD, FTD) ,…
The main goal of the study is to develop and validate a device that provides an objective measure of degradation of motor performance in elderly people. The device will assist to diagnose neurodegenerative disorders in the elderly at an early stage…
The primary aim is to investigate the effects of attentional focus manipulation on the performance of a repetitive leg movement task under single and dual-task conditions in ABI patients. Furthermore, it will be investigated to what extent the…
The purpose of this study is to examine whether walking ability and plantar flexor strength of young children with CP who follow functional power training improve more compared to usual care.
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
2.1 Primary Objectives• Evaluate the safety and tolerability of 2 fixed doses of FRM-0334 (300 and 500 mg daily in 2 sequential periods) over 28 days in subjects with prodromal to moderate FTD-GRN• Assess the PD effects of FRM-0334 on the change…
The objective is to assess the intra-subject reliability of tDCS induced effects on the reaction time in the lower extremities of healthy subjects.
Primary objective of the study: 1. To report on the age-dependency of the effect(s) of MPH or SSRI treatment on the outgrowth of the DA and 5-HT systems, respectively, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques
Primary objective: The ultimate goal is to achieve a more sensitive method for detecting malformations of cortical development. This encompasses two steps: the development of the method and the assessment of the sensitivity and specificity of the…
The purpose of this study is the expansion of the conventional MRI sequences for the diagnosis for patients with probable dementia. The focus is on structural imaging, anatomical and functional connectivity. Patterns of change in brain connectivity…
The purpose of this research line is to assess whether measures acquired with advanced MR neuroimaging can be used as neuropathological markers for the early diagnosis of dementia and differentiation between AD and FTD. For each project, the…