79 results
To investigate in an unselected memory clinic sample, the clinical value of 18F]FBB PET in terms of1. change in diagnosis;2. change in level of confidence of diagnosis;3. impact on patient healthcare management.
The main objective of this study is to find (epi)genetic markers including SNPs/haplotypes, DNA methylation and RNA expression correlating with cognitive decline in clinical patients with Mild Cognitive Impairment (MCI) and Subjective Cognitive…
A. To gain more knowledge about the prevalence of TBI in male prisoners in the PPC and the relationship of TBI with violent crime and aggression. We expect that TBI is more common in violent offenders than in non-violent offenders. More specific, we…
To study the longitudinal dynamics of blood biomarkers, including NfL, in patients with frontotemporal dementia.
The primary objectives are defined according to a hierarchical design: i) to tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in DM2 and MetS; ii) to investigate which cerebral…
The present study will examine how young-onset-dementia patients and their families can be supported in their home environment as long as possible and institutionalisation can be delayed. For this the functioning and care needs of young-onset-…
The current study will focus on the effects of an intensive programme of exposure of prism adaptation (i.e. daily exposure during two weeks) and compare these to sham adaptation.
The most important objective of this study is the validation of various examination procedure to assess fitness to drive in older persons with cognitive impairments. The assessment procedure comprises nosological dementia diagnoses (e.g. AD, FTD) ,…
The main goal of the study is to develop and validate a device that provides an objective measure of degradation of motor performance in elderly people. The device will assist to diagnose neurodegenerative disorders in the elderly at an early stage…
The primary aim is to investigate the effects of attentional focus manipulation on the performance of a repetitive leg movement task under single and dual-task conditions in ABI patients. Furthermore, it will be investigated to what extent the…
Primary Objective: Our main goal is to contribute to the identification of an attentional profile of the paediatric TBI population, by analysing the quality and efficiency of alerting, orienting, executive and sustained attentional functioning. This…
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
1) To determine if microinfarcts can be detected in the brain with 7T MRI in AD patients2) To determine the prevalence and number of cerebral microbleeds on 7T MRI in patients with AD and to relate these lesions to cognition and to the vascular risk…
Primary objective: The ultimate goal is to achieve a more sensitive method for detecting malformations of cortical development. This encompasses two steps: the development of the method and the assessment of the sensitivity and specificity of the…
The purpose of this study is the expansion of the conventional MRI sequences for the diagnosis for patients with probable dementia. The focus is on structural imaging, anatomical and functional connectivity. Patterns of change in brain connectivity…
What are the long-term consequences of prenatal exposure to cannabis and nicotine on the brain development of 6-year old children?
The purpose of this research line is to assess whether measures acquired with advanced MR neuroimaging can be used as neuropathological markers for the early diagnosis of dementia and differentiation between AD and FTD. For each project, the…
The main objective of this study is to characterize the flow of information in the fronto-parietal network during the simulation of movements using intracranial EEG recordings. In the characterization we will pinpoint the neuronal (sub)regions of…
* To implement a standardised MRI acquisition protocol in multiple centres across Europe (Part A).* To identify and evaluate new biomarkers of disease progression in patients with amnestic MCI by collecting biochemical, neuroimaging,…
The primary objective is to evaluate the presence of brain damage (defined by white matter lesions (WMLs) or cerebral atrophy or deviations at neuropsychological examination (NPE)) among adults with tetralogy of Fallot (TOF). The secondary objective…